【摘要】 二硫化钼纳米片（molybdenum disulfide nanosheets,MoS₂NS）是一种新型二维过渡金属硫族化合物，凭借其高比表面积、优异的光电和光热转换性能及可调控的表面化学活性及良好的生物相容性，在电子、储能、光催化、生物医学等领域应用前景广阔，但同时其潜在健康问题也逐渐凸显。本文在概述MoS₂NS结构特点及暴露风险的基础上，归纳其在肝脏、肺、肠道和心脏等主要靶器官中富集特征及毒性效应，重点总结氧化应激、炎症反应、铁死亡等关键分子事件在毒性发生发展中的作用机制。更多还原

【Abstract】 Molybdenum disulfide nanosheets（ MoS₂ NS）,a novel class of two-dimensional transition metal dichalcogenides,possess a high specific surface area,excellent photoelectric and photothermal conversion performance,tunable surface chemical activity,and good biocompatibility. These features support their broad application prospects in electronics,energy storage,photocatalysis,and biomedicine. Meanwhile,their potential health risks have become increasingly evident. This review provides a concise overview of the structural characteristics and exposure risks of MoS₂ NS,and summarizes their enrichment characteristics and toxic effects in major target organs including the liver,lung,intestine,and heart. It highlights the mechanistic roles of key molecular events,including oxidative stress,inflammatory response,and ferroptosis in the development of MoS₂ NS-induced toxicity.更多还原