【摘要】 目的 分析青少年抑郁症患者糖化白蛋白（glycated albumin,GA）水平与睡眠质量、认知功能的相关性。方法 选择2023年1月—2025年1月在我院就诊的120例青少年抑郁症患者作为研究对象纳入抑郁组，依据病情严重程度分为轻度40例、中度42例、重度38例。另选同期于我院体检的100名健康者设为健康组。比较各组GA水平、匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index,PSQI）、重复性成套神经心理状态测验（Repeatable Battery for the Assessment of Neuropsychological Status,RBANS）评分差异。采用Spearman秩相关分析检验以上指标相关性。结果 抑郁组GA水平、PSQI评分均高于健康组，RBANS评分低于健康组（P<0.05）；轻度抑郁组GA水平、PSQI评分均低于中度抑郁组，RBANS评分高于中度抑郁组，中度抑郁组GA水平、PSQI评分均低于重度抑郁组，RBANS评分高于重度抑郁组（P<0.05）；相关性分析显示，青少年抑郁症患者抑郁严重程度、GA水平与PSQI评分呈正相关，与RBANS评分呈负相关（P<0.05）。结论 青少年抑郁症患者抑郁严重程度、GA水平与睡眠质量、认知功能关系密切，青少年抑郁症患者的抑郁严重程度越高，其GA水平上升越显著，同时睡眠质量与认知功能越差。更多还原

【Abstract】 Objective To analyze the correlation between glycated albumin(GA)levels and sleep quality as well as cognitive function in adolescent patients with depression. Methods A total of 120 adolescent patients with depression who visited our hospital from January 2023 to January 2025 were selected as the research subjects and included in the depression group. According to the severity of the disease,they were divided into 40 cases of mild,42 cases of moderate and 38 cases of severe. Another 100 healthy individuals who underwent physical examinations at our hospital’s physical examination center during the same period were selected as the health group. Compare the GA levels,Pittsburgh Sleep Quality Index(PSQI),and Repeatable Battery for the Assessment of each group Neuropsychological Status(RBANS)score. Spearman rank correlation analysis was used to test the correlations of the above indicators. Results The GA level and PSQI score in the depression group were higher than those in the healthy group,while the RBANS score was lower than that in the healthy group(P<0.05). The GA level and PSQI score in the mild depression group were lower than those in the moderate depression group,while the RBANS score was higher than that in the moderate depression group(P<0.05). The GA level and PSQI score in the moderate depression group were lower than those in the severe depression group,and the RBANS score was higher than that in the severe depression group. Correlation analysis showed that the severity of depression and GA level in adolescent patients with depression were positively correlated with the PSQI score,while the severity of depression and GA level were negatively correlated with the RBANS score(P<0.05). Conclusion The severity of depression and GA level in adolescent patients with depression are closely related to sleep quality and cognitive function. The higher the severity of depression in adolescent patients with depression,the more significant the increase in GA level,while the poorer the sleep quality and cognitive function.更多还原