【摘要】 现代社会中随着公民健康意识的提升，针对食管良性狭窄这一常见消化系统疾病，现代主要治疗方式还是给患者植入食管支架，生物可降解食管支架的表现出众，其中的可降解镁合金支架以其生物相容性、可控降解和释放特性，显示出治疗潜力。通过合金化和表面改性，及支架设计上优化结构，实现镁合金支架的耐腐蚀性和生物相容性提升及支架释放控制与力学性能的匹配。随着生物工程材料的发展，可降解生物镁合金支架已成为食管支架研究的热点和前沿。对生物镁合金可降解支架研发的现状进行全面详细综述并对可降解镁合金支架的未来发展进行了展望。更多还原

【Abstract】 Esophageal benign stricture has become a common digestive disease with the improvement of public health awareness. The implantation of an esophageal stent remains the main clinical method to relieve obstruction and improve swallowing. In recent years, biodegradable stents have received increasing attention because they can gradually degrade after fulfilling their function and avoid secondary removal. Among them, biodegradable magnesium alloy stents show great potential due to favorable bio-compatibility, controllable degradation, and ion release capacity. To address the rapid corrosion of magnesium alloys in physiological environments, various strategies have been adopted. Alloying has been used to refine micro-structures and improve corrosion resistance. Surface modification methods, such as micro-arc oxidation, polymer coatings, and composite functional layers, have provided protective barriers and enabled controlled ion release. Structural optimization of stents has also been carried out to achieve a better match between mechanical strength, flexibility, and degradation behavior. These approaches have led to significant improvements in corrosion resistance, bio-compatibility, controlled release, and mechanical compatibility. With the development of biomedical materials and tissue engineering, biodegradable magnesium alloy stents have become a research hot spot. Many in vitro and in vivo studies have confirmed their safety and therapeutic potential. However, challenges remain, including precise control of degradation rate, maintenance of mechanical integrity, and reliable evaluation of long-term biological responses. Future research will likely focus on multifunctional coatings, drug delivery systems, and advanced manufacturing technologies to accelerate clinical translation. In conclusion, biodegradable magnesium alloy stents represent a promising direction for the treatment of esophageal benign stricture. Current progress has demonstrated their feasibility, while ongoing research continues to provide insights into their application and future development.更多还原