【摘要】 目的 探讨依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产新德里金属β-内酰胺酶(NDM)的碳青霉烯耐药大肠埃希菌脓毒症的疗效。方法 根据腹盆增强核磁检查、实验室检查、主要炎症指标(外周血白细胞计数和降钙素原的变化)、药物敏感实验结果，动态调整抗感染方案。结果 依拉环素(50 mg,q12h)联合多黏菌素E甲磺酸钠(150 mg,q12 h)治疗13天后，患者病情好转，炎症指标显著改善，住院期间未发生药物相关不良反应。结论 依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产NDM型金属酶碳青霉烯耐药大肠埃希菌所致的脓毒症安全有效，可为临床治疗产NDM型金属酶碳青霉烯耐药的大肠埃希菌感染提供关键的技术支持。更多还原

【Abstract】 Objective To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase( NDM) secondary to complex intra-abdominal infection. Methods The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI,laboratory tests,changes in main inflammatory indicators( peripheral blood white blood cell count and procalcitonin),and drug sensitivity test results. Results After 13 days of treatment with eravacycline( 50 mg,q12h) and colistimethate sodium( 150 mg,q12h),the patient’s condition and inflammatory indicators improved significantly,with no drug-related adverse reactions during hospitalization.Conclusion The combination is safe and effective for the above-mentioned sepsis,providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.更多还原