【摘要】 目的 分析佛山地区围绝经期妇女维生素D水平及影响因素。方法 回顾性分析2021年4月至2024年7月在佛山市妇幼保健院门诊就诊的300例40～55岁围绝经期妇女的资料，分析其一般资料、症状评分、实验室检查结果、骨密度，采用多因素logistic回归分析围绝经期妇女维生素D水平的影响因素。结果 300例围绝经期妇女的血清25-羟基维生素D[25(OH)D]水平为9.42～56.26 ng/ml，平均（27.10±7.50）ng/ml；维生素D充足100例（33.33%），维生素D不足150例（50.00%），维生素D缺乏50例（16.67%）。三组体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、骨密度比较，差异有统计学意义（P<0.05）。多因素logistic回归分析结果显示，BMI、TC、TG和骨密度是维生素D缺乏的危险因素，HDL-C是维生素D缺乏的保护因素（P<0.05）。结论 佛山地区围绝经期妇女维生素D不足及缺乏的比例较高，BMI、TC、TG、骨密度、HDL-C是佛山地区围绝经期妇女维生素D水平的影响因素，临床应引起足够重视。更多还原

【Abstract】 Objective To analyze the vitamin D levels and influencing factors in perimenopausal period women in Foshan region. Methods A retrospective analysis was conducted on the data of 300 perimenopausal period women aged 40-55 who visited the outpatient department of Foshan Women and Children Hospital from April 2021 to July 2024. General information, symptom scores, laboratory test results, and bone density tests were analyzed, and multiple logistic regression was used to analyze the influencing factors of vitamin D levels in perimenopausal period women. Results The 25 hydroxyvitamin D [25(OH) D] level in 300 perimenopausal period women ranged from 9.42 to 56.26 ng/ml, with an average of(27.10±7.50) ng/ml. A total of 100 cases(33.33%) had sufficient vitamin D, 150 cases(50.00%) had insufficient vitamin D, 50 cases(16.67%) had vitamin D deficiency. There were statistically significant differences in body mass index(BMI), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), and bone density among the three groups(P < 0.05). The results of multiple logistic regression analysis showed that BMI, TC, TG, and bone density were risk factors for vitamin D deficiency, while HDL-C was the protective factor for vitamin D deficiency(P < 0.05). Conclusion The proportion of vitamin D deficiency and insufficiency in perimenopausal period women in Foshan region is relatively high, and BMI, TC, TG, bone density, and HDL-C are influencing factors of vitamin D levels in perimenopausal period women in Foshan region, and should be given sufficient attention in clinical practice.更多还原