【摘要】 目的 了解上海浦东新区健康人群白喉和破伤风抗体水平，完善免疫策略提供科学依据。方法 于2018—2024年采用随机抽样方法选取浦东新区16家社区全年龄段健康人群，收集血清样本并采用酶联免疫吸附试验（ELISA）法检测血清抗白喉、破伤风毒素IgG抗体，分析抗体阳性率（≥0.1 IU/mL）和抗体几何平均浓度（GMC）。结果 共纳入3 312份血清样本，男女性别比为0.76∶1,53.77%为本市户籍。白喉和破伤风抗体阳性率和几何平均浓度（geometric mean concentration,GMC）随年龄增长总体呈下降趋势，但7y-组出现短暂回升。白喉抗体阳性人数为1 175人（35.48%）,GMC为0.054IU/mL。破伤风抗体阳性人数为988人（29.83%）,GMC为0.033 IU/mL。不同年龄组间白喉、破伤风抗体阳性率(χ²_白喉=950.005，χ²_破伤风=1 324.393)和GMC (H_白喉=1 027.160,H_破伤风=1 142.007)差异均有统计学意义（P<0.001）。不同年份间白喉、破伤风抗体阳性率(χ²_白喉=92.913，χ²_破伤风=76.309)和GMC(H_白喉=215.039,H_破伤风=328.317)差异有统计学意义（P<0.001）。结论 浦东新区健康人群白喉和破伤风抗体水平较低，尤其是20岁以上成年人免疫状况较差，应强化6岁以下儿童国家免疫规划疫苗接种规范并开展青少年或成人白破疫苗免疫策略。更多还原

【Abstract】 Objective To understand the antibody levels of diphtheria and tetanus among healthy population in Shanghai Pudong New Area, and to provide a scientific basis for improving the vaccine immunization strategy. Methods Random sampling was used to select healthy people of all ages in 16 communities in Shanghai Pudong New Area from 2018 to 2024,and serum samples were collected and tested for serum anti-diphtheria and tetanus toxin IgG antibodies by enzyme-linked immunosorbent assay（ELISA） method to analyze the antibody positivity rate（≥0.1 IU/ml） and the geometric mean concentration（GMC） of antibodies. Results A total of 3 312 serum samples were included, with a male-to-female ratio of 0.76∶1,and 53.77% were local residents.The seropositivity rates and geometric mean concentrations（GMC） of both diphtheria and tetanus antibodies generally declined with increasing age, but exhibited a transient rebound in the 7y-.A total of 1 175 individuals（35.48%） were seropositive for diphtheria, with a GMC of 0.054 IU/mL.For tetanus, 988 individuals（29.83%） were seropositive, with a GMC of 0.033 IU/mL.Significant differences in seropositivity rates（χ²diphtheria=950.005,χ²tetanus=1 324.393） and GMC(H_diphtheria=1 027.160,H_tetanus=1 142.007) were observed among different age groups（P<0.001）.Significant differences in seropositivity rates（χ²diphtheria=950.005,χ²tetanus=1 324.393） and GMC(H_diphtheria=1 027.160,H_tetanus=1 142.007) were also found across different years（P<0.001）. Conclusion The prevalence of diphtheria and tetanus antibodies in the healthy population of Pudong New Area is relatively low, particularly among adults over 20 years of age with inadequate immunization.This underscores the need to reinforce the National Immunization Program（NIP） vaccine specifications for children under 6 years of age and implement an immunization strategy for adolescents or adults against diphtheria and tetanus.更多还原