【摘要】 蠕虫耐药性的日益严重已成为全球畜牧业可持续发展面临的重大挑战。文章系统分析了蠕虫感染对反刍动物的多重危害，包括生长发育受阻、免疫功能和繁殖性能下降，以及肉奶产量和品质的降低，并列举了临床常用的反刍动物抗蠕虫药物；从蠕虫遗传变异、药物选择压力和管理因素三个维度探讨了蠕虫耐药性产生的原因，并讨论当前蠕虫耐药性的流行现状。在此基础上，提出了科学防控策略：优化驱虫药物使用方案、加快新型抗寄生虫药物研发、推广非药物防控措施以及构建耐药性监测预警体系。旨在为制定有效的蠕虫耐药性防控措施提供科学依据，从而减少经济损失，促进反刍动物养殖业的健康可持续发展。更多还原

【Abstract】 The escalating issue of anthelmintic resistance(AR)in ruminants has emerged as a major challenge to the sustainable development of global livestock production.This paper systematically analyzes the multifaceted detrimental effects of helminth infections on ruminants,including impaired growth and development,compromised immune and reproductive performance,and reduced quantity and quality of meat and milk production and enumerates commonly used anthelmintic drugs in ruminant clinical practice.The underlying causes of AR are thoroughly explored from three dimensions:genetic variability in parasites,drug selection pressure,and management-related factors,followed by a discussion on the current prevalence of AR.Building upon this,scientifically sound mitigation strategies are proposed:optimizing anthelmintic usage protocols,accelerating the development of novel antiparasitic drugs,promoting non-pharmaceutical control measures,and establishing AR monitoring and early-warning systems.This study aims to provide a scientific basis for formulating effective AR control measures,thereby minimizing economic losses and fostering the healthy and sustainable development of ruminant farming.更多还原