【摘要】 目的:探讨血清基质金属蛋白酶9(MMP-9)、增殖细胞核抗原(PCNA)表达与晚期非小细胞肺癌(NSCLC)同步放化疗后预后的相关性。方法:选取128例晚期NSCLC患者作为晚期组，采用简单随机抽样法选取早期NSCLC患者、健康体检者分别作为早期组、对照组，比较3组一般资料。晚期组患者接受同步放化疗，并根据疗效分为预后不良组(疾病稳定、疾病进展)、预后良好组(完全缓解、部分缓解)，比较不同预后患者资料，分析血清MMP-9、PCNA表达与患者预后的相关性。结果:3组血清MMP-9、PCNA表达比较，晚期组大于早期组、对照组，早期组大于对照组(P<0.05);晚期组128例患者最终105例完成治疗，预后良好68例、预后不良37例;预后不良组TNM分期ⅢC占比，血小板淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、MMP-9、PCNA表达高于预后良好组(P<0.05); Logistic回归分析显示，晚期NSCLC同步放化疗后预后不良与PLR、NLR、MMP-9、PCNA表达异常有关(P<0.05);经点二列相关性分析结果显示，血清MMP-9、PCNA表达与晚期NSCLC患者同步放化疗后不良预后风险呈正相关(P<0.05)。结论:血清MMP-9、PCNA在晚期NSCLC中呈异常高表达，且与患者同步放化疗后预后不良风险呈正相关。更多还原

【Abstract】 Objective: To investigate the correlation between serum matrix metalloproteinase-9( MMP-9) and proliferating cell nuclear antigen( PCNA) expression levels and the prognosis of advanced non-small cell lung cancer( NSCLC) after concurrent chemoradiotherapy. Methods: A total of 128 patients with advanced NSCLC were selected as the advanced-stage group,and using simple random sampling,early-stage NSCLC patients and healthy individuals undergoing health check-ups were selected as the early-stage group and control group,respectively. The data of the three groups were compared. Advanced-stage patients received concurrent chemoradiotherapy,and were divided into poor prognosis group( with stable disease or disease progression) and good prognosis group( with complete remission or partial remission) according to the outcomes. The data of patients with different prognoses were compared,and the correlation between the expression levels of serum MMP-9 and PCNA and the prognosis of patients was analyzed. Results: The levels of serum MMP-9 and PCNA in the advanced-stage group were higher than those in both the early-stage group and the control group; additionally,the levels in the early-stage group was higher than those in the control group( P<0.05).Among the 128 patients in the advanced-stage group,105 cases completed the full course of treatment,with 68 having a good and37 having a poor prognosis. The proportion of stage ⅢC,platelet-lymphocyte ratio( PLR),neutrophil-lymphocyte ratio( NLR),and the expression levels of MMP-9 and PCNA in the poor prognosis group were significantly higher than those in the good prognosis group( P<0.05). Logistic regression analysis showed that poor prognosis after synchronous radiotherapy and chemotherapy in advanced NSCLC was associated with abnormal expressions of PLR,NLR,MMP-9,and PCNA( P< 0.05). The results of the two column correlation analysis showed that the serum levels of MMP-9 and PCNA expression were positively correlated with the risk of poor prognosis after concurrent chemoradiotherapy in advanced NSCLC patients( P<0.05). Conclusion: Serum MMP-9 and PCNA expressions are abnormally elevated in advanced NSCLC and are positively correlated with the risk of poor prognosis following concurrent chemoradiotherapy.更多还原