【摘要】 目的 针对现有器官转运设备控温精度不足、温度不均及对外界扰动敏感等不足，研发一套兼具相变蓄冷与主动热电补偿的新型低温灌注转运系统，以提高器官转运过程的温度稳定性与可靠性。方法 构建由EPP-VIP复合包装结构、相变蓄冷模块及双TEC热电补偿装置组成的温控系统，并采用STM32闭环控制算法实现多挡位PWM调节。通过控温能力测试、保温实验及扰动恢复实验系统性评估系统性能。结果 系统在器官灌注目标温区4～8℃内可实现快速降温与高精度稳态控制，稳态温度控制在（6.0±0.3）℃；在连续灌注条件下心脏温度可在（6.0±1.0）℃范围内稳定保持超过66 h；在开盖与间歇灌注等扰动条件下系统温度波动均小于2℃，箱体稳态最大温差较静态保存降低约70%。结论 研究证明该系统具有温控精度高、能耗低、响应快与稳定性强等优势，可为未来高性能器官灌注转运设备的研发提供技术参考。更多还原

【Abstract】 To address the limitations of existing organ transport devices, such as insufficient temperature control accuracy, non-uniform temperature distribution, and sensitivity to external disturbances, the work aims to develop a novel hypothermic perfusion transport system integrating phase-change cold storage with active thermoelectric cooling compensation, thereby improving temperature stability and reliability during organ transportation. A temperature control system composed of an EPP-VIP composite packaging structure, a phase-change thermal storage module, and a dual-TEC thermoelectric compensation unit was designed. A closed-loop control algorithm based on an STM32 microcontroller was implemented to achieve multi-level PWM regulation. The system performance was systematically evaluated through temperature control capability tests, thermal insulation experiments, and disturbance recovery tests. The system achieved rapid cooling and high-precision steady-state temperature control within the target perfusion range of 4-8 °C, maintaining a stable temperature of(6.0±0.3) °C. During continuous perfusion, the heart temperature was stably maintained within(6.0±1.0) °C for more than 66 h. Under disturbances such as lid opening and intermittent perfusion, temperature fluctuations remained below 2 ℃, and the steady-state temperature gradient inside the container was reduced by approximately 70% compared with that in static cold storage. The results demonstrate that the proposed system exhibits high temperature control accuracy, low energy consumption, fast dynamic response, and strong operational stability and the study provides a feasible technical reference for the development of next-generation high-performance organ perfusion transport systems.更多还原