【摘要】 目的：观察十二味参芍益脑合剂治疗偏头痛的临床疗效。方法：选取2024 年4月—2024年10月太和中医院90例肝阳上亢型偏头痛患者，随机分为2组，每组45例。对照组予尼莫地平，治疗组在此基础上联用院内制剂十二味参芍益脑合剂，均治疗4周并随访4周，比较2组头痛相关指标(疼痛程度、持续时间、发作次数)、匹兹堡睡眠质量指数(PSQI)评分、中医证候积分及不良反应。结果：治疗组有效率(93.33%)显著高于对照组(77.78%)；治疗4周后2组头痛指标均改善，但随访4周时仅治疗组维持改善且与对照组差异显著；治疗组治疗及随访4周时PSQI评分、中医证候积分均显著降低，对照组无变化，2组相关指标差异显著，以上差异均有统计学意义；2组均无显著不良反应。结论：十二味参芍益脑合剂联合尼莫地平治疗偏头痛效果显著，可减少发作频率、减轻疼痛、改善睡眠，安全性高。更多还原

【Abstract】 Objective:To observe the clinical efficacy of the Twelve-Ingredient Ginseng and Peony Brain-Nourishing Compound in the treatment of migraine.Methods:Ninety patients with liver-yang hyperactivity type migraine admitted to Taihe Traditional Chinese Medicine Hospital from April to October 2024 were randomly divided into a treatment group (n=45) and a control group (n=45).The control group was given nimodipine,while the treatment group was given the hospital-prepared Twelve-Ingredient Ginseng and Peony Brain-Nourishing Compound in addition to nimodipine.Both groups were treated for 4 weeks and followed up for 4 weeks.The headache-related indicators (pain intensity,duration,frequency),Pittsburgh Sleep Quality Index (PSQI) score,TCM syndrome score,and adverse reactions were compared between the two groups.Results:The effective rate in the treatment group (93.33%) was significantly higher than that in the control group (77.78%).Headache indicators improved in both groups after 4 weeks of treatment,but only the treatment group maintained improvement at 4 weeks of follow-up,with a significant difference compared to the control group.The PSQI score and TCM syndrome score significantly decreased in the treatment group at both the treatment and 4-week follow-up periods,while no change was observed in the control group.The differences in relevant indicators between the two groups were statistically significant.No significant adverse reactions were observed in either group.Conclusion:The combination of the Twelve-Ingredient Ginseng and Peony Brain-Nourishing Compound and nimodipine is effective in treating migraines,reducing attack frequency,alleviating pain,improving sleep,and demonstrating high safety.更多还原