【摘要】 目的 研究川芎嗪对高脂饮食大鼠血脂水平及肝脏脂肪变性的影响。方法 将30只清洁级SD雄性大鼠随机分为空白对照组、模型组、川芎嗪组，每组10只。空白对照组予普通饲料喂养，余组予高脂饮食喂养。同时，川芎嗪组腹腔注射川芎嗪注射液50 mL/（kg·d），模型组腹腔注射等量生理盐水，共给药7周。观察三组整体肝脏组织形态、血脂水平以及苏木精-伊红（HE）染色后显微镜下肝细胞形态。结果 川芎嗪组整体肝脏组织形态介于空白对照组、模型组之间。与空白对照组比较，模型组血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）含量均升高（P<0.05），高密度脂蛋白胆固醇（HDL-C）含量降低（P<0.05），且肝细胞脂肪变性明显。与模型组比较，川芎嗪组TG、LDL-C水平降低（P<0.05）,HDL-C水平升高（P<0.05），且肝细胞脂肪变性减轻。结论 高脂饮食可导致大鼠脂质代谢紊乱，肝脏脂肪变性明显。川芎嗪可改善高脂饮食导致的脂质代谢紊乱、肝脏脂肪变性。更多还原

【Abstract】 Objective To study the effect of Ligustrazine on blood lipids and hepatic steatosis in rats fed a high-fat diet. Methods Thirty clean-grade male SD rats were randomly divided into a blank control group, a model group, and a Ligustrazine group, with 10 rats in each group. The blank control group was fed with ordinary feed, while the other groups were fed with a high-fat diet. Meanwhile, the Ligustrazine group was intraperitoneally injected with Ligustrazine injection at a dose of 50 mL/(kg·d), and the model group was intraperitoneally injected with an equal volume of normal saline. The administration lasted for 7 weeks. The overall liver tissue morphology, blood lipid levels, and hepatocyte morphology under a microscope after hematoxylin-eosin(HE) staining in the three groups were observed. Results The overall liver tissue morphology of the Ligustrazine group was between that of the blank control group and the model group. Compared with the blank control group, the model group showed increased serum levels of total cholesterol(TC), triglyceride(TG), and low-density lipoprotein cholesterol(LDL-C)(P<0.05), decreased level of high-density lipoprotein cholesterol(HDL-C)(P<0.05), and obvious hepatocyte steatosis. Compared with the model group, the Ligustrazine group had reduced levels of TG and LDL-C(P<0.05), increased level of HDL-C(P<0.05), and alleviated hepatocyte steatosis. Conclusion A high-fat diet can cause lipid metabolism disorders in rats, with obvious hepatic steatosis. Ligustrazine can improve lipid metabolism disorders and hepatic steatosis induced by a high-fat diet.更多还原