【摘要】 目的 研究疏肝活血方治疗晚期非小细胞肺癌（Non-small cell lung cancer,NSCLC）气滞血瘀证患者的临床效果。方法选取2022年7月1日—2023年8月31日在漳州市中医院肺病科住院或在门诊就诊的晚期NSCLC患者60例，按随机数字表法分成观察组与对照组，各30例。对照组予常规抗肿瘤治疗，观察组在对照组基础上加用疏肝活血方加减治疗，两组疗程均为28 d。比较两组治疗前后的中医证候积分、焦虑自评量表（SAS）及抑郁自评量表（SDS）评分、凝血指标、免疫指标情况。结果 治疗后，两组中医证候积分、SAS和SDS评分、凝血指标均改善，且观察组均优于对照组（P<0.05）；治疗后，两组免疫指标比较，差异无统计学意义（P>0.05）。观察组中医证候总有效率93.3%(28/30)高于对照组的60.0%(18/30)(P<0.05)。结论疏肝活血方治疗晚期NSCLC气滞血瘀证患者，在改善中医证候积分、焦虑抑郁程度、凝血指标上均有效果，虽对患者免疫功能影响不明显，但仍值得在临床使用及推广。更多还原

【Abstract】 Objective To study the clinical effect of soothing the liver and promoting blood circulation prescription in the treatment of advanced non-small cell lung cancer(NSCLC) with qi stagnation and blood stasis syndrome. Methods Sixty patients with advanced NSCLC who were hospitalized and outpatient in the department of pulmonary disease of Zhangzhou Hospital of Traditional Chinese Medicine from July 1, 2022 to August 31, 2023 were selected. They were randomly divided into an observation group and a control group, with 30 cases in each group. The control group received routine anti-tumor treatment. The observation group was treated with soothing the liver and promoting blood circulation prescription on the basis of the control group for a course of 28 days. The study compared the traditional Chinese medicine(TCM) syndrome scores, self-rating anxiety scale(SAS) scores, self-rating depression scale(SDS) scores, blood coagulation indices, and immune indices between the two groups both before and after treatment. Results After treatment, both groups exhibited improvements in TCM syndrome scores, SAS and SDS scores, and coagulation indices, with the observation group demonstrating significantly better outcomes than the control group(P<0.05). After treatment, no significant differences were observed in immune indices between the two groups(P>0.05). The total effective rate of TCM syndrome in the observation group was 93.3%(28/30), which was notably higher than that in the control group(60.0%, 18/30)(P<0.05). Conclusion The soothing the liver and promoting blood circulation prescription is effective in improving TCM syndrome scores, anxiety and depression, and coagulation indexes. Although it has no obvious effect on patients’ immune function, it can still be used and promoted in clinical practice.更多还原