【摘要】 目的 探讨MRI酰胺质子转移成像联合扩散加权成像在前列腺癌及前列腺增生鉴别诊断中的价值。资料与方法 回顾性分析2020年2月—2021年8月新乡医学院第一附属医院前列腺癌与前列腺增生患者，分为前列腺癌组52例和前列腺增生组60例，分别测量两组的非对称磁化转移率（MTRasym）、表观扩散系数（ADC），并对比分析其差异，比较各参数单独及联合诊断的效能，并分析两参数的相关性。结果 前列腺癌组MTRasym[（3.70±0.94）%]显著高于前列腺增生组[（2.35±0.60）%]（t=8.89,P<0.05）；前列腺癌组ADC值[（0.93±0.15）×10^-3 mm²/s]显著低于前列腺增生组[（1.32±0.22）×10^-3 mm²/s]（t=-11.01,P<0.05）。MTRasym、ADC值及两者联合鉴别前列腺癌和前列腺增生的受试者工作特征曲线下面积分别为0.886、0.914、0.966。MTRasym、ADC值的诊断效能差异无统计学意义（P>0.05），两者联合的诊断效能优于MTRasym、ADC值单独的诊断效能（Z=3.125、2.776,P<0.05）。MTRasym值与ADC值呈负相关（r=-0.469,P<0.001）。结论 酰胺质子转移与扩散加权成像鉴别前列腺癌和前列腺增生均有较高的效能，两序列联合的诊断效能更高。更多还原

【Abstract】 Purpose To explore the value of magnetic resonance amide proton transfer(APT) imaging combined with diffusion weighted imaging(DWI) in the differential diagnosis of prostate cancer and benign prostatic hyperplasia. Materials and Methods A retrospective analysis was made on 52 patients with prostate cancer and 60 patients with benign prostatic hyperplasia in the First Affiliated Hospital of Xinxiang Medical University from February 2020 to August 2021. The APT parameter values magnetization transfer ratio asymmetry(MTRasym) and DWI parameter values apparent diffusion coefficient(ADC) of the two groups were measured, respectively. The parameter differences between the two groups were compared and analyzed, the significant parameters and the efficacy of their joint diagnosis were evaluated. Then compared the performance of each parameter and joint diagnosis, and analyze the correlation between the two parameters.Results The MTRasym in the prostate cancer group [(3.70±0.94)%] was significantly higher than that in the prostate hyperplasia group [(2.35±0.60)%](t=8.89, P<0.05); ADC value in prostate cancer group [(0.93±0.15)×10-3 mm2/s] was significantly lower than that in the prostate hyperplasia group [(1.32±0.22)×10-3 mm2/s](t=-11.01, P<0.05). The areas under the curve for identifying prostate cancer and benign prostatic hyperplasia using MTRasym value, ADC value and their combination were 0.886, 0.914 and 0.966, respectively. There was no statistically significant difference in the diagnostic efficacy between the MTRasym value and the ADC value(P>0.05), and the combined diagnostic efficacy of the two was superior to the individual diagnostic efficacy of the MTRasym value and ADC value(Z=3.125, 2.776,P<0.05). The MTRasym was negatively correlated with the ADC value(r=-0.469, P<0.001). Conclusion APT and DWI have high efficacy in distinguishing between prostate cancer and benign prostatic hyperplasia. The combination of the two sequences has higher diagnostic efficacy.更多还原