【摘要】 随着生活节奏加快、环境污染加剧和精神压力增大，脱发已成为影响公众生活质量的常见皮肤问题。尽管目前治疗脱发的方法有限，但生物活性肽作为一种新型促毛发生长疗法展现出了巨大潜力。本综述讨论了生物活性肽在毛发生长调控中的研究进展，重点探讨其作用机制、分类与来源，以及临床应用现状、潜力与挑战。生物活性肽通过调控Wnt/β-连环蛋白通路、生长因子通路及血管内皮生长因子通路等多种生物学机制，促进毛囊干细胞活化与毛囊生长，同时改善毛囊微环境。单一多肽与聚合多肽在调控毛发生长中各具作用，其中聚合多肽由于其对多种途径的协同作用而具有更广阔的治疗前景。尽管肽类疗法在临床试验中已展现积极效果，但在疗效、稳定性及个体化治疗方面仍面临挑战。未来研究应聚焦于优化肽类递送系统、阐明其作用机制，以推动其在毛发再生领域的广泛应用。更多还原

【Abstract】 With the increasing pace of life, environmental pollution and mental stress, hair loss has become a common skin issue that significantly affects public quality of life.Although the current treatment options for hair loss are limited, bioactive peptides have shown immense potential as a novel therapeutic approach to promote hair growth.This review discusses the research progress of bioactive peptides in hair growth regulation, focusing on their mechanisms of action, classification, sources, as well as their clinical applications, potential, and challenges.Bioactive peptides promote hair follicle stem cell activation and hair follicle growth by modulating multiple biological mechanisms, including the Wnt/β-catenin pathway, growth factor pathways, and VEGF pathways, while improving the hair follicle microenvironment.Single peptides and peptide combinations have distinct roles in regulating hair growth, with peptide combinations offering broader therapeutic prospects due to their synergistic effects on multiple pathways.Although peptide-based treatments have shown promising results in clinical trials, challenges remain regarding efficacy, stability, and personalized treatment.Future research should focus on optimizing peptide delivery systems and clarifying their mechanisms of action to enhance their broad application in hair regeneration.更多还原