【摘要】 目的 观察金匮肾气汤联合M受体拮抗剂治疗膀胱过度活动症的疗效观察。方法 本研究采用随机对照试验方法，选取2023年4月至2024年3月婺源县中医院收治的116例肾气亏虚型膀胱过度活动症患者，采用随机数字表法分为观察组和对照组，每组58例。对照组给予M受体拮抗剂治疗，观察组在接受M受体拮抗剂基础上联合金匮肾气汤治疗。比较2组临床疗效、膀胱过度活动症评分（OABSS）、尿流动力学[最大尿流率（Qmax）及残余尿量（RUV）]的变化、不良反应。结果 观察组有效率为94.8%明显高于对照组82.8%（χ~2=4.245,P=0.039）;2组治疗后2、4周OABSS评分较治疗前均下降，且观察组OABSS评分明显低于对照组（P<0.05）；相比治疗前，2组Qmax上升、RUV降低，且观察组尿动力学指标优于对照组（P<0.05）;2组每日排尿次数在治疗后2、4周后均下降，平均单次排尿量均升高，且与对照组相比观察组指标更佳（P<0.05）；不良反应发生率组间比较差异无统计学意义（χ~2=0.152,P=0.697）。结论 金匮肾气汤联合M受体拮抗剂治疗肾气亏虚型膀胱过度活动症患者疗效显著，能够改善患者尿动力学指标，安全性高，值得临床上推广使用。更多还原

【Abstract】 Objective To observe the therapeutic effect of Jinkui Shenqi decoction combined with M receptor antagonists in the treatment of overactive bladder. Methods This study adopted a randomized controlled trial method. A total of 116 patients with overactive bladder due to kidney qi deficiency who were admitted to Wuyuan County Hospital of Traditional Chinese Medicine from April 2023 to March 2024 were selected and divided into an observation group and a control group by random number table method, with 58 patients in each group. The control group was treated with M receptor antagonists, while the observation group was treated with Jinkui Shenqi decoction on the basis of receiving M receptor antagonists. The changes in clinical efficacy, overactive bladder score(OABSS), urodynamics [maximum urine flow rate(Qmax) and residual urine volume(RUV)], and adverse reactions were compared between the two groups. Results The effective rate of the observation group was 94.8%, significantly higher than that of the control group at 82.8%(χ~2=4.245, P=0.039). The OABSS scores of both groups decreased at 2 and 4 weeks after treatment compared with those before treatment, and the OABSS score of the observation group was significantly lower than that of the control group(P<0.05). Compared with before treatment, Qmax increased and RUV decreased in both groups, and the urodynamic indicators of the observation group were better than those of the control group(P<0.05). The daily urination frequency of both groups decreased 2 and 4 weeks after treatment, and the average single urination volume increased. Moreover, compared with the control group, the indicators of the observation group were better(P<0.05). The comparison of the incidence of adverse reactions between groups was meaningless(χ~2=0.152, P=0.697). Conclusion Jinkui Shenqi decoction combined with M receptor antagonists has a significant therapeutic effect on patients with overactive bladder due to kidney qi deficiency. It can improve the urodynamic indicators of patients and has high safety, making it worthy of clinical promotion and application.更多还原