【摘要】 目的 分析真实世界中安罗替尼不良反应发生率及致药物不良反应（ADR）的影响因素。方法 选取2018年6月至2023年12月滕州市中心人民医院使用安罗替尼的住院患者312例，统计患者基本情况、用药信息和ADR发生情况，并对安罗替尼致ADR的影响因素进行分析。结果 本研究共纳入312例患者，ADR发生率为81.4%，既往慢性病情况（P<0.001）与诊疗前甘油三酯水平（P=0.014）与ADR的发生密切相关。对不良反应分析发现，高龄（P=0.005），既往有慢性病病史（P<0.001），高的体重指数（BMI）水平（P<0.001），用药前高的甘油三酯水平（P<0.001）可促使高血压的发生。女性（P=0.005）伴有高的BMI水平（P<0.001）可促使甘油三酯水平升高。较高的白细胞计数（P<0.001）、中性粒细胞数（P<0.001）及血小板计数（P=0.006）与患者牙痛的发生密切相关。此外，高的BMI水平（P<0.001）可能是引起声音嘶哑的重要原因。结论 安罗替尼致ADR发生率较高，临床使用时应加强对ADR的关注，以减少或避免ADR的发生，确保患者用药安全。更多还原

【Abstract】 Objective To analyze the incidence of adverse reactions(adverse drug reaction, ADR) in the real world. Methods A total of 312 inpatients who used anlotinib in Tengzhou Central People’s Hospital from June 2018 to December 2023 were selected. The basic information of the patients, medication information and the occurrence of ADR were statistically analyzed, and the influencing factors of ADR caused by anlotinib were analyzed. Results A total of 312 patients were included in this study, and the overall incidence of ADR was 81.4%. Previous chronic diseases(P<0.001) and pre-treatment triglyceride levels(P=0.014) were closely related to the occurrence of ADR. Further analysis of the specific adverse reactions showed that advanced age(P=0.005), previous history of chronic disease(P<0.001), high BMI level(P<0.001), and high triglyceride level(P<0.001) could promote the development of hypertension. Women(P=0.005) with high BMI levels(P<0.001) caused the increase of blood triglycerides. Higher leukocyte values(P<0.001), neutrophil number(P<0.001) and platelet value(P=0.006) were closely related to the occurrence of toothache in patients. Moreover, a high BMI level(P<0.001) may be an important cause of hoarseness. Conclusion The incidence of ADR caused by anlotinib is relatively high. During clinical use, more attention should be paid to ADR to reduce or avoid its occurrence and ensure the safety of patients’ medication.更多还原