【摘要】 慢性难愈性创面是一类接受规范系统治疗后仍不能在预期时间内完成结构和功能完全修复的创面。创面愈合是一个复杂的生物学过程，包括炎症反应、细胞增殖迁移和创面重塑。中药以多靶点、多通路的作用能有效抑制炎症因子释放、促进血管新生因子生成、减轻炎症、促进创面肉芽组织血管新生，在创面修复中优势明显。本文通过查阅国内外最新文献对血管新生相关因子及炎症因子在创面愈合的作用、中药干预血管新生相关因子及炎症因子促进创面愈合等方面进行综述，为治疗慢性难愈性创面提供参考。更多还原

【Abstract】 Chronic refractory wounds are a group of wounds that cannot be fully repaired structurally and functionally in the expected time after receiving standardised systemic treatment. Wound healing is a complex biological process, including inflammation, cell proliferation and migration, and wound remodelling. Chinese materia medica can effectively inhibit the release of inflammatory factors, promote the production of angiogenic factors, reduce inflammation, and promote the vascularisation of traumatic granulation tissue with its multi-target and multi-pathway effects, which has obvious advantages in wound repair. This article reviewed the role of angiogenesis-related factors and inflammatory factors in wound healing, and the intervention of Chinese materia medica in angiogenesis-related factors and inflammatory factors to promote wound healing by searching the latest literature at home and abroad, with the aim of providing reference for treatment of chronic refractory wounds.更多还原