【摘要】 目的：对比急性缺血性脑卒中治疗方案中替奈普酶静脉溶栓和动脉溶栓的有效性及安全性。方法：选择2023年1月—12月沈丘县人民医院收治的84例急性缺血性脑卒中患者，采用随机数字表法分为对照组（n=42，替奈普酶静脉溶栓）、研究组（n=42，替奈普酶动脉溶栓）。比较两组治疗有效率、不良反应发生率、神经功能、自理能力及生活质量。结果：研究组治疗有效率高于对照组（P<0.05）；研究组、对照组不良反应发生率比较，差异无统计学意义（P>0.05）；研究组治疗后NIHSS评分低于对照组，BI得分、SF-36评分高于对照组（P<0.05）。结论：替奈普酶治疗急性缺血性脑卒中过程中动脉溶栓方案较静脉溶栓方案的治疗效果好，可促进神经功能改善，提高自理能力及生活质量。更多还原

【Abstract】 Objective: To compare the efficacy and safety of intravenous thrombolysis and arterial thrombolysis in the treatment of acute ischemic stroke. Methods: A total of 84 patients with acute ischemic stroke admitted to Shenqiu County People’s Hospital from January to December 2023 were selected and divided into control group(n=42, intravenous thrombolysis with tenecteplase) and study group(n=42, arterial thrombolysis with tenecteplase) by random number table method. The effective rate, incidence of adverse reactions, neurological function, self-care ability and quality of life were compared between the two groups. Results: The effective rate of treatment in the study group was higher than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the study group and the control group(P>0.05). After treatment, the NIHSS score of the study group was lower than that of the control group, and the BI score and SF-36 score were higher than those of the control group(P<0.05). Conclusion: The therapeutic effect of arterial thrombolysis in the treatment of acute ischemic stroke is better than that of intravenous thrombolysis, which can promote the improvement of neurological function, improve self-care ability and quality of life.更多还原