【摘要】 目的 分析2016—2023年浙江省温州市新报告艾滋病病毒感染者和艾滋病患者（HIV/AIDS）艾滋病抗病毒治疗（ART）及时性及影响因素，为改善HIV/AIDS病例ART效果提供参考。方法 选择2016—2023年温州市新报告HIV/AIDS病例为研究对象，通过中国疾病预防控制信息系统收集人口学信息、首次CD4~+T淋巴细胞（CD4细胞）检测情况、基线CD4细胞计数和ART情况等资料。分析ART及时率，采用多因素logistic回归模型分析HIV/AIDS病例ART及时的影响因素。结果 纳入2016—2023年温州市新报告HIV/AIDS病例4 500例，其中男性3 679例，占81.76%；女性821例，占18.24%。年龄M(Q_R)为46.24(26.23)岁。HIV/AIDS病例ART及时3 606例，ART及时率为80.13%;ART及时率从2016年的57.54%上升至2023年的91.97%(P<0.05)。多因素logistic回归分析结果显示，未婚/离异/丧偶（OR=0.769,95%CI:0.641～0.922）、羁押人员（OR=0.492,95%CI:0.269～0.900）、首次CD4细胞检测不及时（OR=0.278,95%CI:0.234～0.330)、基线CD4细胞计数≥200个/μL(OR=0.709,95%CI:0.595～0.843)或未检测（OR=0.131,95%CI:0.080～0.213）的HIV/AIDS病例ART及时性较低。结论 2016—2023年温州市新报告HIV/AIDS病例ART及时率呈上升趋势，主要受到婚姻状况、病例来源、首次CD4细胞检测及时情况和基线CD4细胞计数的影响。更多还原

【Abstract】 Objective To analyze the timeliness of antir-etroviral therapy(ART) and its influencing factors among newly reported HIV/AIDS cases in Wenzhou City, Zhejiang Province from 2016 to 2023, so as to provide a reference for improving the ART effect of HIV/AIDS cases. Methods Newly reported HIV/AIDS cases in Wenzhou City from 2016 to2023 were selected as the research subjects. Demographic information, the situation of the first CD4~+T lymphocyte(CD4 cell) test, baseline CD4 cell count, and ART situation were collected through the Chinese Disease Prevention and Control Information System. The timely rate of ART was analyzed, and the influencing factors for timely ART among HIV/AIDS cases were analyzed using a multivariable logistic regression model. Results A total of 4 500 newly reported HIV/AIDS cases in Wenzhou City from 2016 to 2023 were included, among which 3 679 were males, accounting for 81.76%, and 821 were females, accounting for 18.24%. The median age was 46.24(interquartile range, 26.23) years.Among these cases, 3 606 received timely ART, with a timely rate of 80.13%. The timely rate of ART increased from57.54% in 2016 to 91.97% in 2023(P<0.05). Multivariable logistic regression analysis showed that unmarried/divorced/widowed(OR=0.769, 95%CI: 0.641-0.922), detainees(OR=0.492, 95%CI: 0.269-0.900), untimely first CD4 cell test(OR=0.278, 95%CI: 0.234-0.330), baseline CD4 cell count ≥200 cells/μL(OR=0.709, 95%CI: 0.595-0.843) or undetected(OR=0.131, 95%CI: 0.080-0.213) were associated with a lower timeliness for ART among HIV/AIDS cases. Conclusion From 2016 to 2023, the timely rate of ART among newly reported HIV/AIDS cases in Wenzhou City showed an upward trend, which was mainly affected by marital status, case source, timeliness of the first CD4 cell test, and baseline CD4 cell count.更多还原