【摘要】 目的：研究脑梗死后抑郁患者幽门螺杆菌(Hp)感染、外周血炎症指标变化及与抑郁程度的相关性。方法：收集70例2023年1月—2024年12月上饶市人民医院神经内科收治的脑梗死后抑郁患者作为试验组，选择同期在本院体检中心健康体检者70例为对照组，比较两组外周血炎症指标、汉密尔顿抑郁量表评分；并检测试验组患者Hp感染情况，根据该情况将其分为Hp阳性组(n=31)及Hp阴性组(n=39)，比较两组外周血炎症指标、抑郁评分，对Hp阳性组行Hp感染根除治疗，观察治疗前及治疗后1、3、6个月Hp阳性组炎症指标、抑郁评分的变化；根据抑郁评分将试验组患者分为轻度抑郁组(n=18)、中度抑郁组(n=39)及重度抑郁组(n=13)，分析Hp感染、外周血炎症指标变化与脑梗死后抑郁程度的相关性。结果：试验组炎症指标水平及抑郁评分较对照组高，差异有统计学意义(P<0.05)；Hp阳性组炎症指标水平及抑郁评分较Hp阴性组高，差异有统计学意义(P<0.05)；重度抑郁组炎症指标水平及Hp感染率较轻度抑郁组与中度抑郁组高，差异有统计学意义(P<0.05)；治疗后1、3、6个月，Hp阳性组炎症指标水平及抑郁评分较治疗前低，差异有统计学意义(P<0.05)；脑梗死后抑郁患者抑郁评分与炎症指标呈正相关(P<0.05)，脑梗死后抑郁患者抑郁程度与Hp感染率呈正相关(P<0.05)。结论：脑梗死后抑郁患者抑郁程度越严重，其炎症指标水平、Hp感染率越高。更多还原

【Abstract】 Objective:To study of Helicobacter pylori (Hp) infection and the changes peripheral blood inflammatory indicators in patients with depression after cerebral infarction and their correlation with depression degree.Method:A total of 70 patients with depression after cerebral infarction in Department of Neurology of Shangrao People’s Hospital were collected from January 2023 to December 2024 and the patients were selected as experiment group,and 70 healthy people in physical examination center of our hospital during the same period were included in control group.The peripheral blood inflammatory indicators and Hamilton depression scale score were compared between two groups.Hp infection status was detected in experiment group,according to infection status,they were divided into Hp positive group (n=31) and Hp negative group (n=39),and the peripheral blood inflammatory indicators and depression score of the two groups were compared.Hp infection eradication therapy was performed in Hp positive group,and the changes of inflammatory indicators and depression score in Hp positive group were observed before treatment and after 1 month and 3 months,6 months of treatment.According to the depression score,the patients in experiment group were divided into mild depression group (n=18),moderate depression group (n=39) and severe depression group (n=13) and the correlation between Hp infection,peripheral blood inflammatory indicators and depression degree after cerebral infarction was analyzed.Result:The inflammatory indicators and depression score in experiment group were higher than those in control group,with statistical differences (P<0.05).The inflammatory indicators and depression score in Hp positive group were higher compared to those in Hp negative group,with statistical differences (P<0.05).The inflammatory indicators levels and Hp infection rate in severe depression group were higher than those in mild depression group and moderate depression group,the differences were statistically significant (P<0.05).At 1 month and 3,6 months after treatment,the inflammatory indicators and depression score in the Hp positive group were lower than those before treatment,with statistical differences (P<0.05).The depression score in patients with depression after cerebral infarction was positively correlated with inflammatory indicators (P<0.05).The degree of depression was positively correlated with Hp infection rate in patients with depression after cerebral infarction (P<0.05).Conclusion:The more severe the degree of depression in patients with depression after cerebral infarction,the higher the levels of inflammatory indicators and Hp infection rate.更多还原