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清开灵注射液治疗急性脑梗死合并肺炎的临床研究

Clinical Study of Qingkailing Injection in the Treatment of Acute Cerebral Infarction Complicated with Pneumonia

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【作者】 文安曹文锋刘世民周勇良冷尔玲

【Author】 WEN An;CAO Wenfeng;LIU Shimin;ZHOU Yongliang;LENG Erling;Department of Neurology, Jiangxi Provincial People’s Hospital;

【通讯作者】 冷尔玲;

【机构】 江西省人民医院(南昌医学院第一附属医院)神经内科中南大学湘雅医院江西医院神经内科江西省人民医院(南昌医学院第一附属医院)新生儿科

【摘要】 目的:探究清开灵注射液治疗急性脑梗死合并肺炎患者的临床效果。方法:选取2023年6月—2024年2月江西省人民医院收治的60例急性脑梗死合并肺炎患者作为研究对象,以治疗方法为分组依据,分为对照组(n=29)及治疗组(n=31)。对照组常规使用抗生素抗感染及对症支持治疗,治疗组则在此基础上,加用清开灵注射液治疗,两组治疗周期均为10~14 d。对比两组治疗效果、WBC、中性粒细胞计数(N)、CRP、改良Rankin量表(mRS)评分、NIHSS评分、体温恢复正常时间、住院天数及不良反应。结果:治疗组总有效率为90.3%,较对照组的62.1%显著高(P<0.05);治疗组治疗后肺炎积分、WBC、N、CRP、mRS评分及NIHSS评分较对照组低(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:清开灵注射液联合抗生素治疗脑梗死合并肺炎的效果明显优于单纯使用抗生素。

【Abstract】 Objective:To explore the clinical effect of Qingkailing Injection on patients with acute cerebral infarction complicated with pneumonia.Method:Sixty patients with acute cerebral infarction complicated with pneumonia admitted to Jiangxi Provincial People’s Hospital from June 2023 to February 2024 were selected as the study objects and divided into control group (n=29) and treatment group (n=31) according to the treatment methods.The control group was routinely treated with antibiotics for anti-infection and symptomatic supportive therapy,on this basis,the treatment group was additionally treated with Qingkailing Injection.The treatment cycle for both groups were 10 to 14 days.The therapeutic effects,WBC,neutrophil (N),CRP,modified Rankin scale (mRS) scores,NIHSS scores,time for body temperature to return to normal,hospital stay and adverse reactions of the two groups were compared.Result:The total effective rate of the treatment group was 90.3%,which was significantly higher than 62.1% of the control group (P<0.05).After treatment,the pneumonia score,WBC,N,CRP,mRS score and NIHSS scores of the treatment group were lower than those of the control group (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The effect of Qingkailing Injection combined with antibiotics in the treatment of acute cerebral infarction complicated with pneumonia is significantly better than that of using antibiotics alone.

【基金】 江西省中医药管理局科技计划项目(2023A0174)
  • 【文献出处】 中国医学创新 ,Medical Innovation of China , 编辑部邮箱 ,2025年23期
  • 【分类号】R563.1;R743.33
  • 【下载频次】23
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