【摘要】 目的:探讨槐杞黄颗粒联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌(PLC)的疗效及对患者肝功能和血管内皮生长因子(VEGF)水平的影响。方法:选取2022年6月至2024年4月本院收治的96例PLC患者，随机分成TACE组(n=48)和研究组(n=48),TACE组仅采取TACE治疗，研究组在TACE组基础上联合槐杞黄颗粒治疗。比较两组患者近期疗效、气阴两虚证积分、卡氏功能状态评分表[(KPS)评定]、肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)]、甲胎蛋白(AFP)、VEGF及不良反应情况。结果:研究组患者客观缓解率为73.33%,优于TACE组患者(52.17%,P<0.05)。治疗后，两组患者气阴两虚证积分、肝功能指标、AFP、VEGF水平均低于治疗前(P<0.05),且研究组患者各指标均低于TACE组(P<0.05)。治疗后，两组患者KPS评分均高于治疗前，且研究组患者评分高于TACE组(P<0.05)。研究组患者胃肠道反应发生率(13.33%)低于TACE组(32.61%,P<0.05),发热、骨髓抑制、出血发生率的组间差异无统计学意义(P>0.05)。结论:槐杞黄颗粒联合TACE治疗PLC,可有效降低患者血清AFP、VEGF水平，明显改善症状及肝功能，显著提高近期疗效，并减少胃肠道反应的发生。更多还原

【Abstract】 Objective:To investigate the efficacy of Huaiqihuang granules combined with transcatheter arterial chemoembolization(TACE) in treating primacy liver cancer(PLC) and its impacts on liver function and vascular endothelial growth factor(VEGF) level in patients. Methods:From June 2022 to April 2024, 96 patients with PLC accepted by our hospital were assigned into a TACE group(n=48, treated with TACE) and a research group(n=48, treated with TACE combined with Huaiqihuang granules) randomly. The short-term efficacy, Qi-Yin deficiency score, health status[evaluated using the Karnofsky Performance Status(KPS)], liver function indicators[alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBil)], alpha fetoprotein(AFP), VEGF, and bad reactions were compared between the two groups.Results:The objective remission rate of the research group was 73.33%, which was higher than the 52.17% in the TACE group(P<0.05). After treatment, the scores of Qi-Yin deficiency syndrome, liver function indicators, AFP, and VEGF levels in both groups were lower than before treatment(P<0.05), and the research group was lower than the TACE group(P<0.05). After treatment, the KPS scores of both groups were higher than before treatment, and the research group was higher than the TACE group(P<0.05). The incidence of gastrointestinal reactions in the research group was 13.33%, which was lower than the 32.61% in the TACE group(P<0.05). There was no great difference in the incidence of fever, bone marrow suppression, and bleeding between the groups(P>0.05).Conclusion:The combination of Huaiqihuang granules and TACE therapy can effectively reduce AFP and VEGF levels in PLC patients, greatly improve symptoms and liver function, greatly enhance short-term efficacy, and reduce the occurrence of gastrointestinal reactions.更多还原