【摘要】 为了克服氟苯尼考水溶性差、生物利用度低和不能饮水给药的缺点，本试验以氟苯尼考为主药，以β-环糊精为辅料，采用环糊精包合技术和喷雾干燥方法，进行了氟苯尼考包合微囊的研制，并对制备的成品进行了溶解性比对试验、溶出度比对试验、稳定性试验和药代动力学试验。结果显示，成功制备出了氟苯尼考环糊精包合微囊，收率为99.6%,15 min溶出度高达93%，产品质量稳定，口服给药后血药浓度达峰时间为1.44 h，峰浓度为15.32μg/mL。结果表明，本方法所制备的氟苯尼考产品水溶性好，体内吸收速度快，血药浓度高，工艺切实可行，已实现产业化生产，可显著提升企业的产品竞争力。更多还原

【Abstract】 To overcome the poor water solubility, low bioavailability, and inability to be administered with drinking water of florfenicol, this study used florfenicol as the active ingredient and β-cyclodextrin as an excipient. The encapsulation technique using cyclodextrin and spray drying method was employed to develop florfenicol encapsulated microcapsules. The prepared products were subjected to solubility comparison tests, dissolution tests, stability tests, and pharmacokinetic studies. The results showed that florfenicol-β-cyclodextrin encapsulated microcapsules were successfully prepared with a yield of 99. 6%, and the dissolution rate reached 93% within 15 minutes. The product exhibited stable quality, and after oral administration, the peak blood concentration was achieved at 1. 44 hours, with a peak concentration of 15. 32 μg/mL. The findings suggest that the florfenicol product prepared by this method has good water solubility, fast absorption, high blood concentration, and a feasible production process, which has already been industrialized. This method significantly improves the competitiveness of the product in the market.更多还原