【摘要】 猪增生性肠病(porcine proliferative enteropathy, PPE)是由胞内劳森菌(Lawsonia intracellularis,LI)感染所引起的一种肠道疾病，感染猪群表现为腹泻、生长速度减慢等症状，严重病例会因肠道出血而发生死亡。该病主要危害在于降低猪群生长速度，影响饲料报酬率，增加料肉比，进而对养猪业造成一定的经济损失。由于该菌体外分离培养困难，在一定程度上阻碍了疫苗的研究进展。目前，国内外对于PPE疫苗研发有弱毒疫苗、灭活疫苗、亚单位疫苗和载体疫苗。这些疫苗虽各具优势，但也仍存在不足之处。因此，现将对PPE疫苗优势及不足作简要综述，以期为PPE新疫苗的研发提供参考。更多还原

【Abstract】 Porcine proliferative enteropathy(PPE) is an intestinal disease caused by infection with Lawsonia intracellular is(LI).Infected swine populations typically exhibit symptoms such as diarrhea and reduced growth rates,with severe cases potentially resulting in death due to intestinal hemorrhaging.The primary impact of this disease lies in its ability to reduce growth rates in pigs,negatively affect feed conversion efficiency,and increase the feed-to-meat ratio,all of which lead to significant economic losses in the swine industry.Due to the difficulty of isolating and cultivating LI in vitro,the development of vaccines has been hindered.Currently,different types of vaccines have been reported for PPE,including attenuated vaccines,inactivated vaccines,subunit vaccines,and vector vaccines.Each of these vaccine types has its own advantages but also limitations.Therefore,this article will briefly review the advantages and disadvantages of PPE vaccines,aiming to provide a reference for the research and development of new PPE vaccines.更多还原