【摘要】 目的 了解福建地区急性出血性结膜炎（Acute hemorrhagic conjunctivitis, AHC）流行情况及疫情暴发的相关影响因素，为制定有效的疫情防控策略提供参考。方法 对福建省AHC流行情况进行描述性统计学分析，对2023年暴发的AHC临床病例标本进行病原检测、VP1区核苷酸全长序列测定、基因型别鉴定和分析。结果 2023年9月份为福建省AHC发病高峰，当月发病人数占全年发病人数的86.39%(5 205/6 025)；发病率处于前3位的地区分别为三明（118.57/10万）、龙岩（53.83/10万）和漳州（16.02/10万）；龙岩市AHC发病率在2011—2022年持续12年处于首位。2023年福建省AHC暴发高峰期采集的62例AHC结膜拭子样本经荧光PCR鉴定结果均为CVA24v，测序共获得60条VP1区完整序列，核苷酸同源性为98.7%～100%，氨基酸同源性为98.4%～100%，与广东省中山市2023年毒株的核苷酸同源性最高为99.0%～100%。2023年福建省毒株属于GⅣ基因型，L16I可能为2023年毒株序列特有的氨基酸变异。结论 导致AHC流行的病原为CVA24v，其所属的GⅣ基因型是我国现阶段流行的优势型别。今后福建省AHC防控应当聚焦于重点城市，并在每年的9月份之前加强全省AHC监测预警，同时及时跟踪了解相关病原基因变异情况。更多还原

【Abstract】 This study was aimed at comprehensively understanding the epidemic status of acute hemorrhagic conjunctivitis(AHC) and influencing factors related outbreak in Fujian Province, to provide valuable insights for AHC prevention and control in this region. We conducted a descriptive statistical analysis of epidemiological data for AHC cases. Additionally, clinical samples collected from a 2023 outbreak were subjected to pathogen detection, determination of full-length nucleotide sequences within the VP1 region, genotype identification, and comprehensive analysis. The peak incidence of AHC in 2023 was observed in September and accounted for a substantial proportion(86.39%,5 205/6 025) of the total cases throughout the year. The three areas with the highest incidence rates were Sanming(118.57/100 000), Longyan(53.83/100 000) and Zhangzhou(16.02/100 000). From 2011 to 2022, the incidence of AHC in Longyan City was the highest for consecutive 12 years. During the peak AHC outbreak period in Fujian Province in 2023, all 62 conjunctival swabs collected were identified as CVA24v, and 60 complete VP1 sequences were obtained through sequencing. The nucleotide sequence identity among these 60 sequences ranged from 98.7% to 100 %, whereas the amino acid identity ranged from 98.4% to 100 %. The highest nucleotide sequence identity was observed for the 2023 strain isolated from Zhongshan, Guangdong Province(rang: 99.0%～100 %). The 2023 strains in Fujian Province belonged to the GIV genotype, and L16I represented a potential unique amino acid variation within the sequence. CVA24v was the causative agent responsible for this AHC epidemic, and its GIV genotype is currently the dominant type in China. Future efforts should prioritize AHC prevention and control measures centered in key cities. Monitoring and early warning of AHC in the whole province should be strengthened before September each year, and the variation of pathogen nucleic should also be tracked in time.更多还原