【摘要】 目的 探究咖啡摄入量与结直肠癌患者全因死亡率的剂量-反应关系，为改善结直肠癌患者的预后提供循证依据。方法 在中国期刊全文数据库、中文科技期刊全文数据库、中国生物医学文献服务系统、万方数据知识服务平台、PubMed、EMBase、Cochrane Library、Web of Science等数据库全面检索咖啡与结直肠癌患者全因死亡率关系的前瞻性队列研究，时间截至2024年12月。按照纳入与排除标准筛选文献并进行文献质量评价和数据提取，使用Stata 18.0软件进行数据分析。结果 共纳入7项研究，涵盖1 320 013例结直肠癌患者，全因死亡人数为11 550例。meta分析结果显示，与不摄入咖啡的结直肠癌患者相比，摄入咖啡的结直肠癌患者的全因死亡风险更低[HR=0.66,95%CI(0.53,0.82)]。咖啡摄入量与结直肠癌患者全因死亡率间呈负向线性关系（χ2=24.10,P<0.01），咖啡摄入每日增加1杯，全因死亡风险降低2%。结论 咖啡摄入量与结直肠癌全因死亡率间存在线性剂量-反应关系，咖啡摄入量的增加可降低结直肠癌患者全因死亡的发生风险。更多还原

【Abstract】 Objective To explore the dose-response relationship between coffee intake and all-cause mortality in patients with colorectal cancer, and to provide evidence-based support for improving the prognosis of patients with colorectal cancer. Methods A comprehensive search was conducted in databases such as China National Knowledge Infrastructure(CNKI), Chinese Science and Technology Journal Full-text Database, China Biomedical Literature Database, Wanfang Data Knowledge Service Platform, PubMed, EMBase, Cochrane Library, and Web of Science for prospective cohort studies on the relationship between coffee intake and all-cause mortality in patients with colorectal cancer, up to December 2024. Literature was screened according to inclusion and exclusion criteria, and quality assessment and data extraction were performed. Data analysis was conducted using Stata 18.0 software. Results A total of 7 studies were included, involving 1 320 013 patients with colorectal cancer, with 11 550 all-cause deaths. The metaanalysis results showed that compared to colorectal cancer patients without coffee intake, those who with coffee intake had a lower risk of all-cause mortality [HR=0.66, 95%CI(0.53, 0.82)]. There was a negative linear relationship between coffee intake and all-cause mortality in patients with colorectal cancer(χ~2=24.10, P<0.01), and for each additional cup of coffee consumed daily, the risk of all-cause mortality decreased by 2%. Conclusions There is a linear dose-response relationship between coffee intake and all-cause mortality in patients with colorectal cancer. An increase in coffee intake can reduce the risk of all-cause mortality in patients with colorectal cancer.更多还原