【摘要】 热休克蛋白(HSPs)作为一类重要的分子伴侣蛋白，在机体内参与多种生物过程。HSPs与多种呼吸系统疾病密切相关，可能是潜在的临床治疗靶点。中药及其活性成分通过影响HSPs及其下游蛋白的表达、调控HSPs相关复合物的形成、减轻气道炎症、降低氧化应激、抑制肺癌细胞的侵袭和迁移、促进肿瘤细胞凋亡等发挥治疗肺部相关疾病的作用。本文综述了HSPs在呼吸系统疾病中的作用以及中药干预HSPs治疗急性肺损伤、慢性阻塞性肺疾病、哮喘、肺癌等的进展，以期为中药机制研究和临床应用提供理论参考和科学依据。更多还原

【Abstract】 Heat shock proteins (HSPs) are important molecular chaperones that are involved in various biological processes.HSPs are closely associated with different respiratory diseases,making them potential targets in the treatment of respiratory diseases.Multiple traditional Chinese medicines and their active components exert therapeutic effect on respiratory diseases by modulating the expression of HSPs and their downstream proteins,and regulating the formation of HSPs-related complexes to alleviate airway inflammation,reduce oxidative stress,inhibit invasion and migration,and promote apoptosis in lung cancer cells.This review summarized the function of HSPs in respiratory diseases and beneficial effects of traditional Chinese medicine for acute lung injury,chronic obstructive pulmonary disease,asthma,lung cancer,etc,via HSPs regulation.We hope to provide theoretical references and scientific evidence for the research and clinical application of traditional Chinese medicine against respiratory diseases.更多还原