【摘要】 糖尿病肾病(DKD)是糖尿病最常见的微血管并发症之一，也是导致慢性肾病和终末期肾病的主要原因。肾脏纤维化是DKD的主要病理特征，而肾脏细胞(上皮细胞或内皮细胞)间充质转化则是促进肾纤维化的关键因素。长链非编码RNA(lncRNAs)是一类非蛋白编码RNA，可在多个层面调控基因表达水平。研究发现，lncRNAs在DKD发生和发展过程中异常表达，并通过调控基因表达参与肾脏细胞间充质转化，进而影响肾脏纤维化。本文综述了近年来相关lncRNAs调控肾脏细胞间充质转化在DKD肾纤维化中的作用及潜在临床应用价值，以期为DKD的防治提供新的思路和靶点。更多还原

【Abstract】 Diabetic kidney disease (DKD),a common microvascular complication of diabetes,is the primary cause of chronic kidney disease and end-stage kidney disease.Renal fibrosis is the main pathological feature of DKD,and the mesenchymal transformation of renal cells (renal epithelial cells or endothelial cells) is a key factor in promoting renal fibrosis.Long non-coding RNAs (lncRNAs) are a class of non-protein coding RNAs that can regulate the gene expression at multiple levels.Recently,many studies have shown that some lncRNAs are abnormally expressed in the development and progression of DKD and involved in the mesenchymal transformation of renal cells by regulating gene expression,thereby affecting renal fibrosis.This article reviews the role and potential clinical application value of lncRNAs in regulating renal cell mesenchymal transformation in DKD renal fibrosis in recent years,to provide new ideas and targets for the prevention and treatment of DKD.更多还原