【摘要】 外泌体是由多种细胞分泌的脂质双分子层囊泡，是细胞间通信的重要介质之一。作为机体免疫系统的重要组成细胞，巨噬细胞对纤维化的进程发挥关键的调控作用。巨噬细胞外泌体通过递送蛋白质、非编码RNA等生物活性分子，或工程化作为药物递送载体，参与到纤维化的进程中，对纤维化的发展和转归起着重要的作用。本文就巨噬细胞外泌体的形成及其在纤维化中的形成过程和工程化应用作一综述，以期为其后续研究和应用提供参考。更多还原

【Abstract】 Exosomes,lipid bilayer vesicles secreted by multiple types cells,are important mediators in intercellular communication.Macrophages are important cells in the body’s immune system,and play a crucial regulatory role in fibrosis.Macrophage exosomes participate in the process of fibrosis by delivering proteins and noncoding RNA,etc.,or function as drug carriers to influence the development and outcome of fibrosis.This article reviewed the formation of macrophage exosomes,their biological functions and engineering applications in fibrosis,to provide insights for future research and engineering application.更多还原