【摘要】 目的：比较乳腺区段切除术与改良根治术治疗早期乳腺癌患者的效果比较。方法：回顾性分析2021年2月至2023年1月该院收治的72例早期乳腺癌患者临床资料，按照手术方法不同将其分为对照组（n=35）与观察组（n=37）。两组均行腋窝淋巴结清扫术治疗，在此基础上，对照组采用改良根治术治疗，观察组行乳腺区段切除术联合腋窝淋巴结清扫术治疗。比较两组围手术期指标（住院时间、切口长度、淋巴结清扫个数、术中出血量、手术时间、总引流量）水平，手术前后肿瘤标志物指标[癌胚抗原（CEA）、糖类抗原153(CA153)、肿瘤异常糖链糖蛋白（TAP）]水平，术后乳房美观度，术后并发症发生率，1年内复发率、转移率和生存率。结果：两组淋巴结清扫个数比较，差异无统计学意义（P>0.05）；观察组住院时间、手术时间、切口长度均短于对照组，总引流量、术中出血量均少于对照组，差异有统计学意义（P<0.05）；术后1个月，两组CA153、TAP水平均低于术前，但组间比较，差异无统计学意义（P>0.05）；两组CEA水平均低于术前，且观察组低于对照组，差异有统计学意义（P<0.05）；观察组乳房美观度优于对照组，差异有统计学意义（P<0.05）；观察组并发症发生率为8.11%(3/37)，低于对照组的25.71%(9/35)，差异有统计学意义（P<0.05）；两组1年内复发率、生存率、转移率比较，差异均无统计学意义（P>0.05）。结论：乳腺区段切除术治疗早期乳腺癌患者可减少术中出血量，缩短住院时间，提高乳房美观度，降低并发症发生率，效果优于改良根治术治疗。更多还原

【Abstract】 Objective: To compare effects of segmental mastectomy and modified radical mastectomy in treatment of patients with early breast cancer. Methods: The clinical data of 72 female patients with early breast cancer admitted to this hospital from February 2021 to January 2023were retrospectively analyzed. According to different surgical methods, they were divided into control group(n=35) and observation group(n=37).Both groups were treated with axillary lymph node dissection. On this basis, the control group was treated with modified radical mastectomy, while the observation group was treated with segmental mastectomy combined with axillary lymph node dissection. The levels of perioperative indexes(hospitalization time, incision length, number of lymph node dissected, intraoperative blood loss, operation time, total drainage volume) and tumor markers [carcinoembryonic antigen(CEA), carbohydrate antigen 153(CA153), tumor abnormal sugar chain protein(TAP)] before and after the surgery, the postoperative breast aesthetics, the incidence of complications, the recurrence rate within 1 year, the metastasis rate, and the survival rate were compared between the two groups. Results: There was no significant difference in the number of lymph node dissected between the two groups(P>0.05). The hospitalization time, the operation time and the incision length of the observation group were shorter than those of the control group,the total drainage volume and the intraoperative blood loss were less than those of the control group, and the differences were statistically significant(P<0.05). One month after the surgery, the levels of CA153 and TAP in both groups were lower than before the surgery, but there were no statistically significant differences between the groups(P>0.05). One month after the surgery, the CEA levels of the two groups were lower than those before the surgery, that of the observation group was lower than that of the control group, and the differences were statistically significant(P<0.05). The breast aesthetics in the observation group were superior to those in the control group, with the difference being statistically significant(P<0.05). The incidence of complications in the observation group was 8.11%(3/37), which was lower than 25.71%(9/35) in the control group, and the difference was statistically significant(P<0.05). There were no significant differences in the recurrence rate, survival rate and metastasis rate between the two groups within 1 year(P>0.05). Conclusions: Segmental mastectomy for the patients with early breast cancer can reduce the intraoperative blood loss,shorten the hospitalization time, improve the breast aesthetics, and reduce the incidence of complications. Moreover, it is superior to modified radical mastectomy treatment.更多还原