【摘要】 糖尿病是慢性牙周炎的高发因素之一，糖尿病患者口腔菌群紊乱，而口腔菌群的异常又会显著影响慢性牙周炎的疾病进展，三者关系紧密且又相互影响。近些年有多项研究通过探索糖尿病、慢性牙周炎及其口腔菌群的多样性，试图揭示糖尿病和慢性牙周炎的疾病规律。因此探索糖尿病和慢性牙周炎与口腔菌群之间的相互关系和关键因素对研究慢性牙周炎和糖尿病的发病机制有非常重要的意义。本文从糖尿病对慢性牙周炎的影响入手，总结慢性牙周炎患者的口腔微生物特点及口腔微生物对慢性牙周炎的影响，分析糖尿病及糖尿病伴慢性牙周炎患者口腔菌群的特点，归纳近些年来研究进展，以期为糖尿病诱发慢性牙周炎的发病机制梳理思路。更多还原

【Abstract】 Diabetes serves as a significant risk factor for the onset of periodontal disease, with diabetic individuals frequently experiencing disruptions in their oral microbiota. These microbial imbalances are substantially associated with the emergence and progression of chronic periodontitis. Diabetes, chronic periodontitis, and oral microbiota are complex and mutually influential. Recent studies have investigated the diversity within these conditions to uncover the underlying patterns. Consequently, examining the interrelationships and key factors among diabetes, chronic periodontitis, and oral microbiota is crucial for clarifying the potential mechanisms that explain a portion of the impact of diabetes on chronic periodontitis. This paper first summarizes the characteristics of oral microorganisms in patients with chronic periodontitis and their influence on the disease. It further analyzes the features of oral microbiota in diabetic patients and those with concurrent diabetes and chronic periodontitis, then reviews recent research advancements. The objective is to provide insights into the pathogenesis of chronic periodontitis as influenced by diabetes.更多还原