【摘要】 目的 对采收自山西省境内连翘(Forsythia suspensa Thunb. vahl)中的生物碱进行研究。方法 综合运用硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层色谱等方法对连翘中的生物碱进行分离纯化，并根据理化性质和波谱数据对其化学结构进行验证。结果 从连翘95%(体积分数)乙醇提取物的酸水萃取部位分离得到14个生物碱和3个木脂素，分别鉴定为：胸腺嘧啶(1)、胸腺嘧啶核苷(2)、2′-甲氧基尿苷(3)、(8R)-7,8-dihydro-8-methyl-5H-cyclopenta[c]pyridin(4)、forsyqinlingine C(5)、forsyqinlingine D(6)、forsyshiyanine B(7)、forsyqinlingine A(8)、forsyqinlingine B(9)、(-)-bicuculline(10)、(-)-egenine(11)、cyclo-(Leu-Tyr)(12)、番荔枝宁(13)、左旋四氢巴马汀(14)、forsythenin(15)、松脂素(16)、异落叶松脂素(17)。结论 化合物1～15为首次从山西产连翘中发现，化合物1～4为首次从连翘中发现，且这4个化合物也是首次从连翘属植物中发现。更多还原

【Abstract】 This study was designed to investigate the alkaloids from Forsythia suspensa Thunb.Vahl collected in Shanxi Province.By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20,the alkaloids were isolated and purified.Seventeen compounds(1-17),including fourteen alkaloids and three lignans, were obtained.Based on the physico-chemical properties and spectral data, their structures were identified as 5-methyluracil(1),thymidine(2),2′-O-methyluridine(3),(8R)-7,8-dihydro-8-methyl-5H-cyclopenta[c]pyridin(4),forsyqinlingine C(5),forsyqinlingine D(6),forsyshiyanine B(7),forsyqinlingine A(8),forsyqinlingine B(9),(-)-bicuculline(10),(-)-egenine(11),cyclo-(Leu-Tyr)(12),xylopinine(13),(-)-tetrahydropalmatine(14),forsythenin(15),pinoresinol(16),isolariciresinol(17).Compounds 1-15 were first isolated from Shanxi-sourced F.suspensa,while compounds 1-4 were first identified in F.suspensa and the genus Forsythia.更多还原