【摘要】 花生四烯酸可通过环氧合酶、脂氧合酶、细胞色素P450酶等代谢通路转化为多种触发炎症反应的代谢产物，在炎症疾病的发生、发展过程中发挥着关键作用。近年来，基于花生四烯酸代谢通路的多靶点药物已成为抗炎药物研究的重要方向并呈现出良好的应用前景。本文总结了花生四烯酸代谢通路及其相互串扰对抗炎药物研发带来的机遇和挑战，随后重点综述了基于花生四烯酸代谢通路的多靶点药物设计、合成及抗炎活性研究进展，最后讨论了花生四烯酸代谢通路多靶点药物在药物研发中的难点与未来发展方向，为基于花生四烯酸代谢通路的多靶点抗炎药物研究提供了参考和借鉴。更多还原

【Abstract】 Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase, lipoxygenase, cytochrome P450 enzymes, and other metabolic pathways.Moreover, it plays a key role in the occurrence and development of inflammatory diseases. In recent years, multitarget drugs based on the arachidonic acid metabolic pathway have become an important direction of antiinflammatory drug research. This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs, reviews the research progress of multi-target drug design, synthesis, and anti-inflammatory activity based on the arachidonic acid metabolic pathway, and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development, aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.更多还原