【摘要】 目的 观察一款222 nm紫外线消毒器在呼吸重症监护室（RICU）对高频接触物体表面和空气的动态消毒效果。方法 以浙江某三级甲等医院RICU的7个独立房间为研究现场，按单双号编号分为对照组（2、4、6号房）和试验组（1、3、5、7号房）。对照组采用常规擦拭+通风消毒，试验组在此基础上使用222 nm紫外线消毒器。连续开展3 d采样，每日8:00—16:00，每2 h采集一次物体表面和空气样本，共计1 050份。检测菌落总数及鲍曼不动杆菌（AB）和肺炎克雷伯菌（KP）。结果 与对照组相比，试验组物体表面和空气的平均菌落总数显著降低（P<0.05）；物体表面平均菌落总数从对照组的（161.63±464.17）cfu/cm~2下降至（54.64±220.59）cfu/cm~2，空气平均菌落数从（215.14±303.88）cfu/m~2下降至（150.65±106.52）cfu/m~2。KP与AB的检出率亦显著下降。结论 222 nm紫外线消毒器在RICU的动态环境下具有良好的消毒效果，能有效降低高频接触表面与空气中的微生物污染，其中在空气消毒方面表现出更为稳定和持续的效果，可作为常规消毒措施的有力补充手段。更多还原

【Abstract】 Objective To evaluate the dynamic disinfection efficacy of a 222 nm ultraviolet(UV) sterilizer on highfrequency contact surfaces and airborne bacteria in a respiratory intensive care unit(RICU). Methods Seven isolated rooms within the RICU of a tertiary hospital in Zhejiang, China, were selected. Rooms were assigned to either a control group(Room 2, 4, 6) receiving routine cleaning and ventilation, or an intervention group(Room 1, 3, 5, 7) receiving additional disinfection using a 222 nm UV sterilizer. Environmental samples were collected continuously for 3 days, with air and surface samples taken every 2 hours from 8:00 to 16:00 daily, totaling 1 050 samples. Bacterial colony counts and detection rates of Acinetobacter baumannii(AB) and Klebsiella pneumoniae(KP) were measured. Results The intervention group showed significantly lower mean colony counts on both surfaces and in air samples compared to the control group(P<0.05). Surface bacterial load was reduced from(161.63±464.17) cfu/cm~2 to(54.64±220.59) cfu/cm~2, while airborne bacterial load decreased from(215.14±303.88) cfu/m~2 to(150.65±106.52) cfu/m~2. The detection rates of AB and KP also decreased significantly in both surface and air samples. Conclusion The 222 nm ultraviolet sterilizer demonstrates significant disinfecting efficacy in the RICU environment. It effectively reduces microbial contamination on surfaces and in the air. Notably, it exhibits more stable and sustained efficacy for air disinfection. This device serves as a robust supplementary measure to routine disinfection protocols.更多还原