【摘要】 骨重建是正畸牙齿移动的核心生物学过程，其动态平衡直接影响牙槽骨吸收与沉积的效率。外力作用会启动对骨重建极为关键的信号级联反应，激活多种细胞信号通路，引发局部骨吸收和沉积。在压力侧，这一过程助力牙齿移动；在张力侧，则促进愈合。其中，激素、全身影响因素、环磷酸腺苷、特定细胞因子，如白细胞介素-1、集落刺激因子、钙、胶原酶以及前列腺素等，都是骨重建所必需的生物学调节的关键成分。那些能够对破骨细胞产生影响以及对骨重建有调节作用的药物，有可能对正畸牙齿移动起到调节效果。本文系统综述了药物通过调节骨代谢关键通路[如破骨细胞分化因子（RANKL）/破骨细胞抑制因子（OPG）、Wnt/β-catenin信号通路]对牙齿骨重建的作用，并探讨其对正畸牙齿移动的潜在调控机制，全面梳理该主题的现有研究证据，明确未来研究的潜在方向。更多还原

【Abstract】 Bone reconstruction is the core biological process of orthodontic tooth movement, and its dynamic balance directly affects the efficiency of alveolar bone resorption and deposition. External forces can trigger a signal cascade reaction that is crucial for bone reconstruction, activate multiple cellular signaling pathways, and cause local bone resorption and deposition. On the pressure side, this process helps the teeth move. On the tension side, it promotes healing. Among them,hormones, systemic influencing factors, cyclic adenosine monophosphate, specific cytokines such as interleukin-1,colony-stimulating factor, calcium, collagenase and prostaglandins, etc., are all key components of biological regulation necessary for bone reconstruction. Drugs that can affect osteoclasts and regulate bone reconstruction may have a regulatory effect on orthodontic tooth movement. This article systematically reviews the effects of drugs on dental bone reconstruction by regulating key pathways of bone metabolism(such as osteoclast differentiation factor [RANKL]/osteoclast inhibitor [OPG],Wnt/β-catenin signaling pathway), and explores their potential regulatory mechanisms on orthodontic tooth movement. It comprehensively reviews the existing research evidence on this topic. Clarify the potential directions for future research.更多还原