【摘要】 目的 探讨人绒毛膜促性腺激素（h CG）日血清黄体生成素（LH）水平对体外受精-胚胎移植后活产率（LBR）的预测价值。方法 对2017年6月至2024年4月在天津医科大学总医院行拮抗剂方案接受体外受精-胚胎移植且首次新鲜周期移植的378例女性患者进行回顾性队列研究。所有患者均采用促性腺激素释放激素（GnRH）拮抗剂方案进行促排卵治疗，并根据h CG日血清LH水平将患者分为低LH组（LH≤1.67U/L）和高LH组（LH>1.67U/L）。评估hCG日LH水平、体重指数（BMI）、卵巢储备功能等因素对妊娠结局的影响。结果 低LH组和高LH组生化妊娠率、临床妊娠率、活产率的差异无统计学意义（P>0.05）。回归分析显示，女方年龄、移植胚胎数和子宫内膜厚度与活产率显著相关（P<0.05）。hCG日LH水平对妊娠结局的预测作用未显示独立性，而年龄和子宫内膜厚度可能是活产率的更强预测因子。结论 h CG日LH水平作为独立预测因子在体外受精-胚胎移植后的活产率预测中没有显著作用，其可能并不是影响妊娠结局的决定性因素。年龄和子宫内膜厚度等因素在预测体外受精-胚胎移植后活产率中起到了重要作用，提示体外受精-胚胎移植治疗的成功率应结合多项生理指标进行个性化评估。更多还原

【Abstract】 Objective To assess the value of the serum luteinizing hormone(LH)level on the human chorionic gonadotropin(hCG)administration day for predicting the live birth rate(LBR)after in vitro fertilization-embryo transfer(IVF-ET)treatment.Methods This was a retrospective cohort study.A total of 378 female patients were included,who underwent IVF-ET treatment with the gonadotropin-releasing hormone (GnRH) antagonist protocol and had their first fresh cycle embryo transfer at Tianjin Medical University General Hospital from June 2017 to April 2024.All patients received ovulation induction treatment with the GnRH antagonist protocol and were divided into a low-LH group(LH≤1.67U/L)and a high-LH group(LH>1.67U/L)according to the serum LH level on the hCG administration day.Evaluate the effects of such factors as the LH level on the h CG administration day,body mass index(BMI),and ovarian reserve function on the pregnancy outcome.Results There were no significant differences in the biochemical pregnancy rate,clinical pregnancy rate,or live birth rate between the low-LH group and high-LH group(P>0.05).However,the regression analysis showed that female age,the number of transferred embryos,and the thickness of the endometrium were significantly correlated with the live birth rate(P<0.05).The predictive role of the LH level on the hCG administration day in the pregnancy outcome did not show independence,while age and endometrial thickness might be stronger predictors for the live birth rate.Conclusions The LH level on the hCG administration day,as an independent predictor,does not play a significant role in the prediction of the live birth rate after treatment,indicating that it might not be a decisive factor affecting the pregnancy outcome.Nevertheless,such factors as age and endometrial thickness play an important role in predicting the live birth rate,suggesting that the success rate of IVF-ET treatment should be evaluated individually by combining multiple physiological indicators.更多还原