【摘要】 目的 探讨足月脑损伤新生儿伴不同程度宫内酸中毒的危险因素。方法 采用病例对照研究方法，收集2016年1月1日至2021年12月31日深圳市人民医院产科住院分娩的发生脑损伤的足月新生儿463例，其中发生宫内酸中毒的219例为病例组，未发生宫内酸中毒的244例为对照组。根据pH结果将病例组分为轻度酸中毒组（7.0≤pH<7.2）和重度酸中毒组（pH<7.0），分别与对照组进行比较。采用二元logistic回归分析危险因素。结果分娩方式、电子胎心监护异常、胎盘早剥是足月脑损伤新生儿伴宫内酸中毒的危险因素（P<0.05）。其中电子胎心监护异常在重度酸中毒组的OR值（3.854）高于轻度酸中毒组（2.503）。胎盘早剥是重度酸中毒组的危险因素（OR=20.691）。结论 胎盘早剥、电子胎心监护异常的足月脑损伤新生儿更容易出现重度宫内酸中毒，临床处理时应高度重视。更多还原

【Abstract】 ObjectiveTo explore the risk factors for different degrees of intrauterine acidosis in full-term infants with brain injury.MethodsA case-control study was conducted to collect a total of 463 full-term infants with brain injury who were born at the Obstetrics Department of Shenzhen People’s Hospital from January 1,2016 to December 31,2021.A total of 219 full-term brain injury infants with intrauterine acidosis were selected as the case group,and 244 full-term brain injury infants without intrauterine acidosis were selected as the control group. According to the pH value,the case group was subdivided into a mild acidosis group (7.0 ≤ pH<7.2)and a severe acidosis group (pH<7.0),and was compared with the control group. Binary logistic regression was used to analyze risk factors.ResultsMode of delivery,abnormal electronic fetal monitoring,and placental abruption were risk factors for intrauterine acidosis in full-term infants with brain injury (P<0.05).The OR value of abnormal electronic fetal monitoring in the severe acidosis group (3.854) was higher than that in the mild acidosis group (2.503). Placental abruption was a risk factor for severe acidosis (OR=20.691).Conclusion Full-term newborns with brain injury who also have placental abruption and abnormal electronic fetal monitoring are more likely to develop severe intrauterine acidosis,necessitating close clinical attention.更多还原