【摘要】 目的 分析江苏省乙型病毒性肝炎(乙肝)相关疾病住院患者的经济负担及其影响因素。方法 2023年5-12月在江苏省3个地区12家医院选取乙肝相关疾病住院患者开展问卷调查，收集患者相关医疗费用信息，分析经济负担构成、总经济负担和影响总经济负担的因素。结果 共纳入508例乙肝相关疾病住院患者，总经济负担费用为5 559.99万元，其中直接、间接、无形经济负担分别占21.77%、3.94%和74.28%;慢性乙肝、重型乙肝、肝硬化、原发性肝癌患者总经济负担分别占47.77%、3.00%、39.74%、9.48%。所有患者总经济负担费用的中位数为4.22万元，其中直接、间接、无形经济负担分别为1.26万元、0.26万元、1.00万元，慢性乙肝、重型乙肝、肝硬化、原发性肝癌患者分别为2.45万元、8.22万元、4.41万元、7.99万元。在所有患者的直接经济负担中，直接医疗、非医疗费用分别占78.52%、21.48%。多元线性回归分析显示，年龄、家庭年收入、疾病类型、住院时间、核苷酸类似物和干扰素治疗、并发症、医疗保险类型是乙肝相关疾病总经济负担的影响因素。结论 江苏省乙肝相关疾病经济负担较重;需强化重点人群乙肝疫苗接种、乙肝早期筛查和治疗。更多还原

【Abstract】 Objective To explore the economic burden of hospitalization for hepatitis B-related diseases in Jiangsu province and factors influencing economic burden.Methods We recruited individuals hospitalized for hepatitis B-related diseases from 12 hospitals in 3 prefectures of Jiangsu for a questionnaire-based survey during May to December 2023. We collected medical cost data to determine economic burden composition,total economic burden,and factors influencing total economic burden.Results Five hundred eight inpatients were recruited. The total economic burden was 55 599. 9 thousand yuan,in which direct,indirect,and intangible economic burdens accounted for 21. 77%,3. 94%,and 74. 28% of total burden;burdens for chronic hepatitis B,severe hepatitis B,liver cirrhosis,and primary liver cancer accounted for47. 77%,3. 00%,39. 74%,and 9. 48% of total economic burden. The median total economic burden was 42. 2 thousand yuan,with median direct,indirect,and intangible burdens being 12. 6,2. 6,and 10. 0 thousand yuan; median burdens for chronic hepatitis B,severe hepatitis B,liver cirrhosis,and primary liver cancer were 24. 5,82. 2,44. 1,and 79. 9 thousand yuan. Direct medical and non-medical costs accounted for 78. 52% and 21. 48% of direct economic burden. Multivariate linear regression analysis showed that age,annual household income,disease type,hospitalization duration,nucleotide analogue or interferon treatment,complications,and types of medical insurance were factors associated with total economic burden.Conclusions The economic burden was heavy among individuals hospitalized for hepatitis B-related diseases in Jiangsu. We should enhance hepatitis B vaccination and early screening and treatment for priority populations.更多还原