【摘要】 目的 对中国人乳头瘤病毒(Human Papillomavirus,HPV)疫苗犹豫实证研究进行系统评价和Meta分析。方法 利用8种中英文文献数据库检索截止到2024年1月24日发表的我国HPV疫苗犹豫实证研究。对纳入文献进行质量评价,采用R软件(4.0.0)进行贝叶斯Meta分析,进而分析其研究设计、理论模型及影响因素。结果 系统评价共纳入15项研究。研究的目标人群主要为女性和女孩家长。贝叶斯Meta分析共纳入13项研究,结果显示我国HPV疫苗犹豫率为31.00%(95%CI:17.00～48.30)。亚组分析结果显示,研究对象本人和监护人的疫苗犹豫率分别为35.04%(95%CI:16.72～57.53)和28.26%(95%CI:4.54～72.33);东部和西部地区分别为21.67%(95%CI:6.02～48.41)和32.82%(95%CI:6.64～72.30);本科及以下和硕士研究生及以上人群分别为28.51%(95%CI:2.91～80.53)和19.15%(95%CI:0.19～95.70);医学和非医学专业人群分别为26.21%(95%CI:4.52～64.03)和32.17%(95%CI:3.62～81.11)。纳入研究的理论模型包括3Cs(Complacency、Confidence、Convenience),PAPM (Precaution Adoption Process Model)和5Cs (Confidence、Constraints、Complacency、Calculation、Collective responsibility)。疫苗犹豫产生原因主要为疫苗信心不足、认知程度和接种的便利性问题。个人态度因素、储备知识程度和人口学因素是影响疫苗犹豫程度的重要因素。结论 当前证据显示,我国疫苗犹豫程度较高,不同特征的人群疫苗犹豫率存在差异。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。更多还原

【Abstract】 Objective To systematically review empirical studies of Human papilomavirus(HPV) vaccine hesitancy(VH) in China.Methods Eight academic research databases were used to search for empirical studies on HPV VH in China published up to January 24,2024.The included studies were evaluated for quality and Bayesian Meta-analysis was performed using R(4.0.0).Study designs,theoretical models and influencing factors were analyzed afterwards.Results This systematic review included 15 studies.The subjects of included studies were mainly women and guardians of girls.Bayesian Meta-analysis included 13 studies,and the result showed that HPV VH in China was 31.00%(95% CI:17.00-48.30).Subgroup analysis showed that VH of the subjects themselves and their guardians were 35.04%(95% CI:16.72-57.53) and 28.26%(95% CI:4.54-72.33),respectively.The percentages of VH in the eastern and western regions were 21.67%(95% CI:6.02-48.41) and 32.82%(95% CI:6.64-72.30).The percentages of VH for those with a bachelor’s degree or below and those with a postgraduate degree or above were 28.51%(95% CI:2.91-80.53)and 19.15%(95% CI:0.19-95.70).The percentages of VH for those with a medical and non-medical background were26.21 %(95% CI:4.52-64.03) and 32.17%(95% CI:3.62-81.11).The theoretical models of the empirical studies included 3Cs(Complacency,Confidence,Convenience) model,PAPM(Precaution Adoption Process Model) and5Cs(Confidence,Constraints,Complacency,Calculation,Collective responsibility).VH arose due to low vaccine confidence,cognition,and incommodity of vaccination.Attitudes,knowledge and demographic factors were important influencing factors of VH.Conclusion Current evidence indicates that VH is common in China,with varying rates among different demographic groups.Due to the limited quantity and quality of the included studies,more high-quality studies are needed to verify the above conclusion.更多还原