【摘要】 目的 探讨某钢铁厂工人尿中多环芳烃（PAHs）代谢物与认知功能之间的关系。方法 2019年，抽取山西省某焦化厂的960名工人进行基本情况调查、认知功能测试和尿中多环芳烃羟基代谢物（OH-PAHs）检测。于2023年随访，共567名工人完成认知功能测试。采用北京版蒙特利尔认知评估量表MoCA）测试工人认知功能；使用高效液相色谱–串联质谱联用（HPLC-MS/MS）检测尿中OH-PAHs。使用广义线性模型和广义估计方程分析工人尿中OH-PAHs与认知功能的关系。结果 调查对象基线年龄49(46,53)岁，其中，男性占91.7%。纵向研究中，2–羟基萘（2-OHNAP）和1-OHPYR高暴露组的注意力（β=–0.338,95%CI=–0.454～–0.222,P<0.001;β=–0.450,95%CI=–0.557～–0.343,P<0.001）、抽象思维（β=–0.463,95%CI=–0.549～–0.377,P<0.001; β=–0.360,95%CI=–0.450～–0.269,P<0.001）及总得分（β=–0.863,95%CI=–1.284～–0.443,P<0.001; β=–0.548,95%CI=–0.987～–0.108,P=0.015）降低。结论 长期暴露于高浓度多环芳烃环境中可能会导致钢铁厂工人认知功能降低。更多还原

【Abstract】 Objective To investigate the relationship between the metabolites of polycyclic aromatic hydrocarbons(PAHs) in urine and the changes in cognitive function of steel mill workers. Methods In 2019, 960 workers from a coking plant in Shanxi province were selected to undergo basic information investigations, cognitive function tests, and detection for hydroxylated metabolites of polycyclic aromatic hydrocarbons(OH-PAHs) in urine. During the follow-up in2023, a total of 567 workers completed the cognitive function tests. The Beijing version of the Montreal Cognitive Assessment(MoCA) was employed to test the cognitive function of the workers. High performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS) was utilized to detect OH-PAHs in urine. The generalized linear model and the generalized estimation equation were adopted to analyze the relationship between urinary OH-PAHs and the cognitive function of the workers. Results Subjects were 49(46, 53) years old at baseline, with 91.7% being the male. In the longitudinal study, the high exposure groups of 2-hydroxynaphthalene(2-OHNAP) and 1-hydroxypyrene(1-OHPYR) showed decreases in attention(β = –0.338, 95%CI: –0.454 to –0.222, P < 0.001; β = –0.450, 95%CI: –0.557 to –0.343, P < 0.001), abstract thinking(β = –0.463, 95%CI: –0.549 to –0.377, P < 0.001; β = –0.360, 95%CI: –0.450 to–0.269, P < 0.001) and the total score(β = –0.863, 95%CI: –1.284 to –0.443, P < 0.001; β = –0.548, 95%CI: –0.987 to–0.108, P = 0.015). Conclusions Long-term exposure to high concentrations of PAHs can lead to reduced cognitive function in steel mill workers.更多还原