【摘要】 目的 系统分析上海市丙型肝炎（丙肝）综合监测数据，为上海市推动丙肝危害消除工作提供科学依据。方法 基于上海市丙肝综合监测工作，获得2020—2023年丙肝病例报告、病原学分型、哨点监测等数据，分析本市丙肝的发病趋势和分布特征、基因分型、高风险/重点人群的感染状况。结果上海市2020—2023年急性丙肝年均报告发病率为0.04/10万，慢性丙肝年均报告发病率为6.93/10万，慢性病例以男性、中老年和中心城区人群为主。基因亚型中，1b（占40.36%）、3b（占14.80%）、3a（占11.43%）、6a（占10.09%）和6n（占6.05%）亚型为HCV流行的主要型别。吸毒者（31.88%）、丙肝患者家属（10.00%）和因肝病死亡人群（6.00%）的HCV抗体阳性率，显著高于其他高风险/重点人群。就诊人群的HCV抗体阳性率检测结果显示，肝病科（4.79%）、中医/针灸科（2.53%）、全科门诊（1.85%）、血透室（1.58%）和感染科/传染科（1.41%）是医疗机构发现丙肝感染者的重点科室。结论 2020—2023年上海市丙肝呈低流行水平，吸毒者、丙肝患者家属等人群中感染率较高。进一步优化和完善丙肝综合监测系统，对及时掌握丙肝的流行特征、高风险/重点人群的感染状况，合理配置医疗卫生资源具有重要的公共卫生意义。更多还原

【Abstract】 Objective To systematically analyze the integrated surveillance data of hepatitis C(HC) in Shanghai and provide a scientific basis for the elimination of HC. Methods The reported HC cases, hepatitis C virus(HCV)genotypes, and sentinel surveillance data were collected based on the integrated HC surveillance work in Shanghai from 2020 to 2023. The incidence trend, distribution, HCV genotypes, and high-risk/key populations of HC in Shanghai were analyzed. Results The reported incidences of acute and chronic HC in Shanghai from 2020 to 2023 were 0.04/100 000and 6.93/100 000, respectively. The reported chronic cases were mainly males, middle-aged and elderly people, and downtown residents. Genotypes 1b(40.36%), 3b(14.80%), 3a(11.43%), 6a(10.09%), and 6n(6.05%) were the principal subtypes of HCV. The HCV antibody-positive rate in drug users, family members of HC patients, and people who died of liver disease were 31.88%, 10.00%, and 6.00%, respectively, which were significantly higher than that in other highrisk/key populations. The departments of hepatology(4.79%), traditional Chinese medicine/acupuncture and moxibustion(2.53%), general outpatient(1.85%), hemodialysis(1.58%), and infectious diseases(1.41%) were the key departments of medical institutions with higher HCV-antibody positive rates. Conclusions HC was low-epidemic in Shanghai from2020 to 2023, with higher infection rates observed among drug users and family members of HC patients. Optimization of the integrated surveillance system for HC is of great value for understanding the epidemiological characteristics,infection status of high-risk/key populations, rational allocation of medical and health resources, and promoting the elimination of HC.更多还原