【摘要】 目的 采用Meta分析方法评价囊内注射聚桂醇和无水乙醇硬化方式治疗单纯性肝囊肿的有效性和安全性。方法 系统检索国内外数据库中比较聚桂醇和无水乙醇硬化治疗单纯性肝囊肿的临床对照研究，采用RevMan5.4软件进行Meta分析。结果 共纳入25篇原始文献。Meta分析结果显示：聚桂醇组总有效率远高于无水乙醇组(95%CI:2.57～6.98);聚桂醇组术后3个月、6个月囊肿体积缩小程度均大于无水乙醇组(95%CI:-35.49～-12.46、-46.23～-18.22);术后1周、6个月肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]指标聚桂醇组低于无水乙醇组(术后1周ALT、AST,95%CI:-18.33～-8.55、-48.72～-27.07;术后6个月ALT、AST,95%CI:-11.95～-4.13、-16.99～-4.51);且聚桂醇组住院时间更短、并发症的发生率更低，安全性较好。结论 超声引导下囊内注射聚桂醇硬化治疗单纯性肝囊肿安全有效，疗效优于无水乙醇，对肝功能影响更小、并发症更少、住院时间更短，值得临床推广应用。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of intracystic polidocanol and absolute ethanol sclerotherapy for simple hepatic cysts using meta-analysis. Methods Controlled clinical studies comparing polidocanol and absolute ethanol sclerotherapy were systematically retrieved from domestic and international databases. Meta-analysis was performed using RevMan 5.4 software. Results A total of 25 original studies were included. The meta-analysis results demonstrated that overall response rate in the polidocanol group was significantly higher than that in the absolute ethanol group(95%CI: 2.57 to 6.98). The reduction in cyst volume at both 3 months and 6 months postoperatively was significantly greater in the polidocanol group compared to the absolute ethanol group(95%CI:-35.49 to-12.46 and-46.23 to-18.22, respectively). The liver function indicators [alanine amino-transferase(ALT) and aspartate transferase(AST)] were significantly lower in the polidocanol group than in the absolute ethanol group at both time points: At postoperative week 1: ALT(95%CI:-18.33 to-8.55), AST(95%CI:-48.72 to-27.07); At postoperative month 6: ALT(95%CI:-11.95 to-4.13), AST(95%CI:-16.99 to-4.51). Furthermore, the polidocanol group exhibited a shorter hospitalization, lower complication rates, and superior safety profile. Conclusions Ultrasound-guided intracystic polidocanol sclerotherapy is an effective and safe intervention for simple hepatic cysts, demonstrating superior efficacy, reduced hepatotoxicity, fewer complications, and shorter hospitalization compared to absolute ethanol. Its clinical adoption is strongly recommended.更多还原