【摘要】 目的 探讨帕罗西汀联合丁螺环酮治疗焦虑症女性患者的疗效及对神经递质、正念思维、炎症细胞因子的影响。方法 选择2021年7月—2023年6月于丽水市第二人民医院治疗的焦虑症女性患者92例，依据随机数字表法分为联合组46例、对照组46例，对照组行丁螺环酮治疗，联合组行帕罗西汀+丁螺环酮治疗。治疗前后，观察两组焦虑、睡眠情况；血清神经肽(NPY)、脑源性神经营养因子(BDNF)等神经递质水平，正念思维，血清白细胞介素-10(IL-10)、白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)等炎症细胞因子水平。观察两组不良反应。结果 治疗后，联合组SAS评分、HAMA评分、PSQ评分均低于对照组[(30.29±3.26)分vs.(38.17±4.20)分]、[(3.58±0.37)分vs.(6.19±0.64)分]、[(8.57±0.88)分vs.(10.75±1.31)分],差异有统计学意义(P<0.05);联合组血清NPY、BDNF水平高于对照组[(155.07±18.15)pg/ml vs.(132.09±15.33)pg/ml]、[(14.47±1.62)μg/L vs.(10.72±1.31)μg/L],差异有统计学意义(P<0.05);联合组FFMQ评分高于对照组[(134.28±15.38)分vs.(123.69±14.11)分],差异有统计学意义(P<0.05);联合组血清IL-10、IL-1β及TNF-α水平低于对照组[(127.39±14.55)pg/ml vs.(150.57±17.81)pg/ml]、[(2.55±0.27)pg/ml vs.(2.69±0.28)pg/ml]、[(10.95±1.22)pg/ml vs.(12.08±1.34)pg/ml],差异有统计学意义(P<0.05)。联合组总有效率高于对照组(P<0.05)。治疗期间，两组均无严重不良反应发生。结论 帕罗西汀联合丁螺环酮治疗焦虑症女性患者可减轻其焦虑症状，提高疗效，纠正神经递质异常表达，促进患者建立正念思维，抑制炎症反应，安全性高。更多还原

【Abstract】 Objective To study the effects of paroxetine combined with buspirone on neurotransmitters, mindful thinking and inflammatory factors in female patients with anxiety disorder.Methods Ninety-two female patients with anxiety disorder who were treated in our hospital from July 2021 to June 2023 were divided into a combination group(46 case) and a control group(46 case) according to random number table method.The control group received buspirone treatment, and the combination group received paroxetine + buspirone treatment.Before and after treatment, the anxiety and sleep of the two groups were observed.Serum neuropeptide(NPY), brain-derived neurotrophic factor(BDNF) and other neurotransmitters, Mindful thinking, Serum levels of inflammatory factors such as interleukin-10(IL-10), interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α).Side effects.Results After treatment, SAS scores, HAMA scores and PSQ scores of the combined group were lower than those of the control group [(30.29±3.26) scores vs.(38.17±4.20) scores], [(3.58±0.37) scores vs.(6.19±0.64) scores], [(8.57±0.88) scores vs.(10.75±1.31) scores](P<0.05); The levels of serum NPY and BDNF in combination group were higher than those in control group [(155.07±18.15) pg/ml vs.(132.09±15.33) pg/ml] and [(14.47±1.62) μg/L vs.(10.72±1.31) μg/L](P<0.05).The FFMQ score of the combined group was higher than that of the control group [(134.28±15.38) scores vs.(123.69±14.11) scores](P<0.05).Serum levels of IL-10, IL-1β and TNF-α in the combination group were lower than those in the control group [(127.39±14.55) pg/ml vs.(150.57±17.81) pg/ml] and [(2.55±0.27) pg/ml vs.(2.69±0.28) pg/ml], [(10.95±1.22) pg/ml vs.(12.08±1.34) pg/ml](P<0.05).The total effective rate of combination group was higher than that of control group(P<0.05).During treatment, no serious side effects occurred in both groups.Conclusion Paroxetine combined with buspirone in the treatment of anxiety in female patients can reduce anxiety symptoms, improve efficacy, correct abnormal expression of neurotransmitter, promote the establishment of mindful thinking, inhibit inflammatory response, and have high safety.更多还原