【摘要】 目的 本研究旨在探讨卵圆孔未闭（PFO）相关隐源性穿支动脉梗死（PI）患者的临床特征及超声心动图改变。方法 回顾性纳入2015年1月—2023年12月确诊为隐源性卒中的患者，通过经颅多普勒超声（TCD）发泡试验诊断PFO。比较PI患者中对比PFO-PI组与非PFO-PI组的临床特征及经胸超声心动图检查（TTE）结果，在PFO组患者中比较PI与皮质梗死（CI）的差异。结果 研究共纳入251例患者进行回顾性分析。104例患者检出PFO，其中40.4%(42/104)为PFO-PI,59.6%(62/104)为PFO-CI。在未合并PFO的患者中，30.6%(45/147)为非PFO-PI。与非PFO-PI患者相比，PFO-PI患者椎基底动脉系统梗死（VCI）比例显著升高（47.6%vs 17.8%,P=0.003）；左心室舒张末期内径（LVEDd）均数更小（47.3 mm vs 49.8 mm,P=0.037;E波峰值流速（Em）更低（62.6 cm/s vs 70.8 cm/s,P=0.015）。在PFO患者中，与PFO-CI组（34.5 mm和49.4 mm）相比，PFO-PI组主动脉根部内径（ARd）均数更小（32.5 mm,P=0.011）,LVEDd均数更低（47.3 mm,P=0.045）。结论 PFO-PI患者中VCI发生率更高。同时，LVEDd减小，Em降低以及较小的ARd是与PFO-PI相关的三项超声心动图特征。更多还原

【Abstract】 Objective We sought to investigate the clinical characteristics and echocardiographic changes of cryptogenic perforator infarction(PI) patient with patent foramen ovale(PFO).Methods From Jan 2015 to Dec 2023, patients diagnosed with cryptogenic stroke were retrospectively included in our study. All patients received transthoracic echocardiography(TTE) and transcranial Doppler(TCD). PFO was diagnosed by the bubble test of TCD. Comparisons of clinical features and TTE findings were performed firstly in PI patients, between PFO and non-PFO, and then in patients with PFO, between PI and cortical infarction(CI).Results A total of 251 patients were retrospectively analyzed. PFO was detected in 104 patients,of those,40. 4%(42/104) had pure PI(PFO-PI) and 59. 6%(62/104) had CI(PFO-CI). In patients without PFO,30. 6%(45/147) had pure PI(non-PFO-PI). Compared with non-PFO-PI, PFO-PI associated with a higher proportion of vertebrobasilar circulation infarctions(VCI)(47. 6% vs 17. 8%, P=0. 003), lower mean value of left ventricle end-diastolic diameters(LVEDd)(47. 3 mm vs 49. 8 mm, P=0. 037) and lower peak E-wave velocity(62. 6 cm/s vs 70. 8 cm/s,P=0. 015). In PFO patients, PFO-PI was detected with a lower mean value of aorta root diameters(32. 5 mm,P=0. 011) and lower mean value of LVEDd(47. 3 mm,P=0. 045) than PFO-CI(34. 5 mm and 49. 4 mm, respectively).Conclusion Higher proportion of VCI was found in PFO-PI. Lower LVEDd, lower Em and without aortic root dilatation were three echocardiographic features associated with PFO-PI in cryogenic PI patients.更多还原