【摘要】 心源性栓塞是由心脏疾病引起的特殊类型的缺血性卒中，其发生与心脏结构和功能的异常紧密相关，这类卒中的病理生理机制复杂，多由心脏疾病导致的血栓形成、脱落进入脑血管，引发缺血性损伤及后续级联反应。炎症反应在心源性栓塞发生发展中扮演至关重要的角色，参与血栓的形成到栓塞急性期脑损伤再到短期神经功能的恢复及预测长期预后，还可以作为生物标志物及诊断因素。本文通过总结炎症在心源性栓塞发生发展过程中的作用机制，归纳了当前研究在心源性栓塞的病因、卒中后神经功能的恢复、个性化治疗策略、预后预测等方面的进展，从而深入理解机制，识别抗炎治疗靶点并优化诊疗策略。更多还原

【Abstract】 Cardioembolic stroke is a special type of ischemic stroke caused by cardiac diseases, and its development is closely associated with the structural and functional abnormalities of the heart. The pathophysiological mechanisms of this type of stroke are complex. It is often induced by thrombosis due to cardiac diseases, followed by thrombus detachment and entry into cerebral vessels, leading to ischemic injury and subsequent cascade reactions. Inflammatory response plays a crucial role in the development and progression of cardioembolic stroke, being involved in processes ranging from thrombosis to acute-phase brain injury after embolism, short-term neurological recovery, and long-term prognosis prediction, and can also be used as a biomarker and diagnostic factor. This article summarizes the mechanism by which inflammation contributes to the development and progression of cardioembolic stroke, as well as the current research advances in the etiology of cardioembolic stroke, the recovery of neurological function after stroke, and personalized treatment strategies.更多还原