【摘要】 目的 前哨性头痛（SH）是指患者在发生脑卒中前7 d内出现的新发头痛或改变特征的原有头痛。本研究分析SH在卒中患者中的发生率、临床特征及其与预后相关性。方法 依据纳排标准收集并入组2022年8月—2023年4月因脑卒中在西安交通大学第一附属医院神经内科住院的患者145例，收集患者一般信息，根据是否出现SH分为头痛组与对照组，归纳分析SH的特点，在1年后随访分析SH与预后相关性。结果 共入组卒中患者145例，共30例出现SH(20.7%)，其中，脑出血9例（25.7%），脑梗死15例（18.9%）,TIA 3例（14.3%）,SAH 3例（30.0%）。结论 所有卒中患者均可能出现SH,SH发生率为20.7%;SH的特点表现为：类偏头痛样头痛、类紧张型头痛、类丛集性头痛；目前结果尚未发现卒中患者的1年期预后与前哨性头痛的相关性，后续需要进一步深入研究。更多还原

【Abstract】 Objective Sentinel headache(SH) refers to new-onset headache or existing headache with altered characteristics that occurs within seven days before stroke in patients, and this study aims to investigate the incidence rate and clinical features of SH in stroke patients and its association with prognosis.Methods A total of 145 stroke patients who were admitted to Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, from August 2022 to April 2023 were enrolled based on inclusion/exclusion criteria, and general information was collected. According to the presence or absence of SH, they were divided into headache and control group. The features of SH were summarized, and follow-up was performed after 1 year to analyze the association between SH and prognosis.Results Among the 145 patients with stroke,30(20. 7%) developed SH, with the subtypes of intracerebral hemorrhage(9 patients, 25. 7%), cerebral infarction(15 patients,18. 9%), transient ischemic attack(3 patients,14. 3%), and subarachnoid hemorrhage(3 patients, 30. 0%).Conclusion SH may occur in all stroke patients, with a prevalence rate of 20. 7%. The manifestations of SH include migraine-like headache, tension-type headache, and cluster-like headache. The results of this study do not establish an association between SH and 1-year prognosis in stroke patients,and further studies are needed in the future.更多还原