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姜黄属中药多糖的药理活性及其作用机制研究进展

Research progress on pharmacological activity and mechanism of traditional Chinese medicine polysaccharides of Curcuma

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【作者】 赵芃钰任虹徐李缘娄鸣凤卿莹林丽婷朱宗萍廖婉

【Author】 ZHAO Pengyu;REN Hong;XU Liyuan;LOU Mingfeng;QING Ying;LIN Liting;ZHU Zongping;LIAO Wan;Chengdu University of Traditional Chinese Medicine;

【通讯作者】 廖婉;

【机构】 成都中医药大学

【摘要】 姜黄属Curcuma隶属于姜科,常用中药姜黄、莪术、郁金及片姜黄均来源于该属植物。姜黄属中药的主要药效成分为姜黄素类和挥发油类,近年来姜黄属中药的多糖成分因具有多种药效活性而备受关注。现代药理学研究表明,多糖作为姜黄属中药的主要活性成分之一,具有抗氧化、抗肝纤维化、抗肿瘤、抗溃疡、降血糖、增强免疫、抗炎、抗凝血等药理活性,已成为姜黄属中药开发应用研究的热点之一。基于国内外对姜黄属中药多糖的研究报道,系统地总结了姜黄属中药多糖的植物来源、提取、分离和纯化方法、结构特征、药理活性及其潜在机制,为姜黄属中药多糖的进一步研究和开发提供一定的科学依据。

【Abstract】 Curcuma belongs to the Zingiberaceae family, the common traditional Chinese medicine Jianghuang(Curcumae Longae Rhizoma), Ezhu(Curcumae Rhizoma), Yujin(Curcumae Radix) and Pianjianghuang(Wenyujin Rhizoma Concisum) all derived from this genus. The main active components of Curcuma are curcumin and volatile oils. In recent years, the polysaccharide components of Curcuma have attracted much attention due to their various medicinal activities. Modern pharmacological studies have shown that polysaccharide, as one of the main active components of Curcuma, has many pharmacological activities such as anti-oxidation, antiliver fibrosis, antitumor, anti-ulcer, hypoglycemia, immune-enhancing, anti-inflammatory, and anti-coagulation. It has become one of the hotspots in the development and application of Curcuma. Based on the research reports on polysaccharides of Curcuma at home and abroad, this paper systematically summarized the plant sources, extraction, isolation and purification methods, structural characteristics, pharmacological activities and potential mechanisms of polysaccharides of Curcuma to provide a certain scientific basis for the further research and development of polysaccharides of Curcuma.

【基金】 国家自然科学基金资助项目(82274099);四川省科技厅面上项目(24NSFSC1101)
  • 【文献出处】 中草药 ,Chinese Traditional and Herbal Drugs , 编辑部邮箱 ,2025年14期
  • 【分类号】R285.5
  • 【下载频次】204
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