【摘要】 目的 探索儿童青少年血清维生素D（VD）水平与血脂异常的关联。方法 采用多阶段分层随机整群抽样方法选取1873名6～18岁儿童青少年，进行问卷调查、体格检查、血脂代谢指标及血清25羟维生素D[25（OH）D]水平检测，采用非条件Logistic回归分析25（OH）D水平与血脂异常关联。结果 血清VD水平与TC、LDL-C浓度呈正相关，与TG负相关(r_TC=0.167,r_TG=-0.139,r_LDL-C=0.144；均P<0.001)；将VD水平按四分位数分组,调整了性别、年龄、地区、睡眠、中高强度体力活动，每日户外活动、营养素补充剂摄入等因素后，Logistic回归分析结果显示，与VD水平处于第四分位数者相比，VD水平处于第一分位数者TC、LDL-C异常风险显著降低(OR_TC=0.306;95%CI:0.171～0.549;OR_LDL-C=0.287;95%CI:0.151～0.545),VD水平处于第三分位数者TG异常风险显著升高(OR_TG=1.764;95%CI:1.183～2.632)。结论 血清VD对不同血脂成分影响不同，低水平VD与TC、LDL-C异常风险较低相关，与TG异常风险较高相关。[营养学报，2025,47（3）:239-244]更多还原

【Abstract】 Objective To investigate the correlation between serum vitamin D(VD) levels and dyslipidemia in children and adolescents. Methods A total of 1873 children and adolescents aged 6 to 18 years were selected through multi-stage stratified random cluster sampling. Questionnaire surveys and physical examination were performed. Lipid profiles and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The association between 25(OH)D levels and dyslipidemia was analyzed using unconditional Logistic regression. Results Serum VD levels were positively correlated with TC and LDL-C concentrations and negatively correlated with TG levels(r TC=0.167, r TG=-0.139, r LDL-C=0.144; All P<0.001). After adjusted for gender, age, region, sleep, moderate-to-high-intensity physical activity, daily outdoor activities, and nutrient supplement intake, logistic regression analysis indicated that those in the lowest quartile(first quartile) had a significantly lower risk of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) abnormalities compared with individuals in the highest quartile of VD levels(fourth quartile)(ORTC=0.306;95%CI: 0.171-0.549;ORLDL-C=0.287;95%CI:0.151-0.545). In contrast, individuals in the third quartile of VD levels exhibited a higher risk of triglyceride(TG)abnormalities compared with individuals in the highest quartile of VD levels(fourth quartile)(ORTG=1.764;95%CI: 1.183～2.632).Conclusion Serum VD has different effects on different lipid components. Lower VD levels are associated with a reduced risk of TC and LDL-C abnormalities but an increased risk of TG abnormalities. [ACTA NUTRIMENTA SINICA,2025,47(3):239-244]更多还原