节点文献
双氯芬酸钠缓释片联用排石颗粒致严重药物性肝损伤及全身皮疹1例
A Case of Severe Drug-induced Liver Injury and Systemic Rash Caused by Diclofenac Sodium Sustained-release Tablets Combined with Paishi Granules
【摘要】 1例患者因肾结石,为了缓解疼痛,门诊给予排石颗粒和双氯芬酸钠缓释片。患者当晚将排石颗粒5 g(1袋)和双氯芬酸钠缓释片75 mg一同服下,患者出现全身皮疹伴瘙痒症状,肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(T-BiL)、直接胆红素(D-BiL)、碱性磷酸酶(ALP)均高出正常上限2~6倍,发生严重不良反应。经对症治疗后,患者皮疹消退,肝功能指标基本恢复正常。
【Abstract】 One patient with kidney stones was prescribed Paishi granules and diclofenac sodium sustained-release tablets for pain relief in the outpatient setting. That evening, the patient took 1 sachet of Paishi granules and 1 diclofenac sodium sustained-release tablet together. The patient subsequently developed a generalized rash with itching. Liver function indexes of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(T-BiL), direct bilirubin(D-BiL), and alkaline phosphatase(ALP) were all 2 to 6 times higher than the upper limit of normal. After symptomatico treatment, the patients systemic rash had subsided, and the liver function indicators have returned to normal.
【Key words】 Diclofenac sodium sustained-release tablets; Paishi granules; Drug-induced liver Injury; Systemic rash;
- 【文献出处】 医药导报 ,Herald of Medicine , 编辑部邮箱 ,2025年10期
- 【分类号】R969.3
- 【下载频次】64