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双氯芬酸钠缓释片联用排石颗粒致严重药物性肝损伤及全身皮疹1例

A Case of Severe Drug-induced Liver Injury and Systemic Rash Caused by Diclofenac Sodium Sustained-release Tablets Combined with Paishi Granules

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【作者】 靳梦亚; 巩颖; 顾媛媛; 张彦丽; 刘甜甜; 赵雪; 刘文亚; 李志远;

【Author】 JIN Mengya;GONG Ying;GU Yuanyuan;ZHANG Yanli;LIU Tiantian;ZHAO Xue;LIU Wenya;LI Zhiyuan;Department of Pharmacy, Dongfang Hospital, Beijing University of Chinese Medicine;Department of Pharmacy, Beijing Jishuitan Hospital, Capital Medical University;

【机构】 北京中医药大学东方医院药学部; 首都医科大学附属北京积水潭医院中药房;

【摘要】 1例患者因肾结石,为了缓解疼痛,门诊给予排石颗粒和双氯芬酸钠缓释片。患者当晚将排石颗粒5 g(1袋)和双氯芬酸钠缓释片75 mg一同服下,患者出现全身皮疹伴瘙痒症状,肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(T-BiL)、直接胆红素(D-BiL)、碱性磷酸酶(ALP)均高出正常上限2~6倍,发生严重不良反应。经对症治疗后,患者皮疹消退,肝功能指标基本恢复正常。

【Abstract】 One patient with kidney stones was prescribed Paishi granules and diclofenac sodium sustained-release tablets for pain relief in the outpatient setting. That evening, the patient took 1 sachet of Paishi granules and 1 diclofenac sodium sustained-release tablet together. The patient subsequently developed a generalized rash with itching. Liver function indexes of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(T-BiL), direct bilirubin(D-BiL), and alkaline phosphatase(ALP) were all 2 to 6 times higher than the upper limit of normal. After symptomatico treatment, the patients systemic rash had subsided, and the liver function indicators have returned to normal.

【基金】 北京市中医管理局临床药学重点专科(ZZ-2013-35);北京市中医管理局北京市第三批中药骨干人才培养项目(京中医科字[2022]67号-16);2023年全国中药特色技术传承人才培训项目(T20234832005);北京积水潭医院院级科研基金项目(YGQ-2202119);北京中医药大学青年教师项目(2019-JYB-JS-103);国家自然科学基金青年科学基金项目(82104627)
  • 【文献出处】 医药导报 ,Herald of Medicine , 编辑部邮箱 ,2025年10期
  • 【分类号】R969.3
  • 【下载频次】64
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