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免疫检查点抑制剂相关急性肾损伤的危险因素及临床管理
Risk factors and clinical management of acute kidney injury associated with immune checkpoint inhibitors
【摘要】 免疫检查点抑制剂在肿瘤免疫治疗中取得显著效果,但其引发的肾脏并发症,尤其是急性肾损伤的发生率不断升高。本文综合现有文献,分析免疫检查点抑制剂相关急性肾损伤的发生情况和危险因素,并总结其诊断与管理策略。
【Abstract】 Immune checkpoint inhibitors have demonstrated significant efficacy in tumor immunotherapy, but the incidence rate of renal complications, especially acute kidney injury, caused by them continues to increase. This article synthesizes existing literature, analyzes the occurrence and risk factors of acute kidney injury related to immune checkpoint inhibitors,and summarizes its diagnosis and management strategies.
【关键词】 急性肾损伤;
免疫检查点抑制剂;
免疫治疗;
免疫相关不良事件;
【Key words】 Acute kidney injury; Immune checkpoint inhibitors; Immunotherapy; Immune-related adverse events;
【Key words】 Acute kidney injury; Immune checkpoint inhibitors; Immunotherapy; Immune-related adverse events;
【基金】 国家自然科学基金资助项目(82230021、82170702);国家重点研发计划项目(2021YFC2500204)
- 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2025年20期
- 【分类号】R692
- 【下载频次】35